5FUK
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6VZX
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![BU of 6vzx by Molmil](/molmil-images/mine/6vzx) | Structure of a Covalently Captured Collagen Triple Helix using Lysine-Glutamate Pairs | 分子名称: | collagen mimetic peptide | 著者 | Miller, M.D, Hulgan, S.A, Xu, W, Kosgei, A.J, Phillips Jr, G.N, Hartgerink, J.D. | 登録日 | 2020-02-28 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Covalent Capture of Collagen Triple Helices Using Lysine-Aspartate and Lysine-Glutamate Pairs. Biomacromolecules, 21, 2020
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6XDM
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6TK7
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![BU of 6tk7 by Molmil](/molmil-images/mine/6tk7) | Femtosecond to millisecond structural changes in a light-driven sodium pump: Dark structure in acidic conditions | 分子名称: | EICOSANE, RETINAL, Sodium pumping rhodopsin | 著者 | Skopintsev, P, Ehrenberg, D, Weinert, T, James, D, Kar, R, Johnson, P, Ozerov, D, Furrer, A, Martiel, I, Dworkowski, F, Nass, K, Knopp, G, Cirelli, C, Gashi, D, Mous, S, Wranik, M, Gruhl, T, Kekilli, D, Bruenle, S, Deupi, X, Schertler, G.F.X, Benoit, R, Panneels, V, Nogly, P, Schapiro, I, Milne, C, Heberle, J, Standfuss, J. | 登録日 | 2019-11-28 | 公開日 | 2020-05-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Femtosecond-to-millisecond structural changes in a light-driven sodium pump. Nature, 583, 2020
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7NY8
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![BU of 7ny8 by Molmil](/molmil-images/mine/7ny8) | Affimer K69 - KRAS protein complex | 分子名称: | Affimer K69, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Turner, A.L, Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. | 登録日 | 2021-03-21 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021
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8FC9
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![BU of 8fc9 by Molmil](/molmil-images/mine/8fc9) | Cryo-EM structure of the human TRPV4 - RhoA, apo condition | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ... | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8OV4
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6Q3C
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![BU of 6q3c by Molmil](/molmil-images/mine/6q3c) | CDK2 in complex with FragLite1 | 分子名称: | 4-bromo-1H-pyrazole, Cyclin-dependent kinase 2 | 著者 | Wood, D.J, Martin, M.P, Noble, M.E.M. | 登録日 | 2018-12-04 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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6XIH
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7NT6
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![BU of 7nt6 by Molmil](/molmil-images/mine/7nt6) | CryoEM structure of the Nipah virus nucleocapsid spiral clam-shaped assembly | 分子名称: | Nucleoprotein, RNA (42-MER), RNA (48-MER) | 著者 | Ker, D.S, Jenkins, H.T, Greive, S.J, Antson, A.A. | 登録日 | 2021-03-09 | 公開日 | 2021-07-07 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | CryoEM structure of the Nipah virus nucleocapsid assembly. Plos Pathog., 17, 2021
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6Q5R
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![BU of 6q5r by Molmil](/molmil-images/mine/6q5r) | Crystal structure of a CC-Hex mutant that forms an antiparallel four-helix coiled coil CC-Hex*-LL-KgEb | 分子名称: | CC-Hex*-LL-KgEb, GLYCEROL | 著者 | Beesley, J.L, Rhys, G.G, Wood, C.W, Brady, R.L, Woolfson, D.N. | 登録日 | 2018-12-09 | 公開日 | 2019-05-22 | 最終更新日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Navigating the Structural Landscape of De Novo alpha-Helical Bundles. J.Am.Chem.Soc., 141, 2019
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6XLV
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7AAP
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![BU of 7aap by Molmil](/molmil-images/mine/7aap) | Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP | 分子名称: | MAGNESIUM ION, Non-structural protein 12, Non-structural protein 7, ... | 著者 | Naydenova, K, Muir, K.W, Wu, L.F, Zhang, Z, Coscia, F, Peet, M, Castro-Hartman, P, Qian, P, Sader, K, Dent, K, Kimanius, D, Sutherland, J.D, Lowe, J, Barford, D, Russo, C.J. | 登録日 | 2020-09-04 | 公開日 | 2020-09-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NT5
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![BU of 7nt5 by Molmil](/molmil-images/mine/7nt5) | CryoEM structure of the Nipah virus nucleocapsid single helical turn assembly | 分子名称: | Nucleoprotein, RNA (78-MER) | 著者 | Ker, D.S, Jenkins, H.T, Greive, S.J, Antson, A.A. | 登録日 | 2021-03-09 | 公開日 | 2021-07-07 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | CryoEM structure of the Nipah virus nucleocapsid assembly. Plos Pathog., 17, 2021
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7O9J
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![BU of 7o9j by Molmil](/molmil-images/mine/7o9j) | Crystal structure of DyP-type peroxidase from Dictyostelium discoideum in complex with an activated form of oxygen | 分子名称: | 1,2-ETHANEDIOL, DyPA, OXYGEN MOLECULE, ... | 著者 | Rai, A, Fedorov, R, Manstein, D.J. | 登録日 | 2021-04-16 | 公開日 | 2021-07-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum . Int J Mol Sci, 22, 2021
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7O9L
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![BU of 7o9l by Molmil](/molmil-images/mine/7o9l) | Dictyostelium discoideum dye decolorizing peroxidase DyPA in complex with cyanide. | 分子名称: | 1,2-ETHANEDIOL, CYANIDE ION, DyPA, ... | 著者 | Rai, A, Fedorov, R, Manstein, D.J. | 登録日 | 2021-04-16 | 公開日 | 2021-07-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum . Int J Mol Sci, 22, 2021
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6QB3
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![BU of 6qb3 by Molmil](/molmil-images/mine/6qb3) | Apo Mcl1 in a complex with a scFv | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, scFv55 | 著者 | Kazmirski, S, Hargreaves, D. | 登録日 | 2018-12-20 | 公開日 | 2019-11-06 | 最終更新日 | 2019-11-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1. Acta Crystallogr D Struct Biol, 75, 2019
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8S33
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![BU of 8s33 by Molmil](/molmil-images/mine/8s33) | Malic semialdehyde dehydrogenase (MSA-DH) from Acinetobacter baumannii | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Succinate-semialdehyde dehydrogenase [NAD(P)+] | 著者 | Piskol, F, Lukat, P, Blankenfeldt, W, Jahn, D, Moser, J. | 登録日 | 2024-02-19 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Biochemical and structural elucidation of the L-carnitine degradation pathway of the human pathogen Acinetobacter baumannii Front Microbiol, 2024
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8GMK
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![BU of 8gmk by Molmil](/molmil-images/mine/8gmk) | Pyruvate bound structure of Citrate Synthase (CitA) in Mycobacterium Tuberculosis | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PYRUVIC ACID, ... | 著者 | Pathirage, R, Ronning, D, Yamsek, M. | 登録日 | 2023-03-26 | 公開日 | 2023-06-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
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6Q3B
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![BU of 6q3b by Molmil](/molmil-images/mine/6q3b) | CDK2 in complex with FragLite2 | 分子名称: | 4-IODOPYRAZOLE, Cyclin-dependent kinase 2 | 著者 | Wood, D.J, Martin, M.P, Noble, M.E.M. | 登録日 | 2018-12-04 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | 主引用文献 | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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7RBZ
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![BU of 7rbz by Molmil](/molmil-images/mine/7rbz) | X-ray Structure of SARS-CoV-2 main protease covalently modified by compound GRL-017-20 | 分子名称: | 3C-like proteinase, 5-chloropyridin-3-yl 2,3-dihydro-1H-indole-4-carboxylate | 著者 | Mesecar, A.D, Anson, B.A, Ghosh, A.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-06 | 公開日 | 2021-09-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. J.Med.Chem., 64, 2021
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7U59
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6Q49
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![BU of 6q49 by Molmil](/molmil-images/mine/6q49) | CDK2 in complex with FragLite6 | 分子名称: | 4-bromanyl-1~{H}-pyridin-2-one, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE | 著者 | Wood, D.J, Martin, M.P, Noble, M.E.M. | 登録日 | 2018-12-05 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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7U7H
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![BU of 7u7h by Molmil](/molmil-images/mine/7u7h) | Cysteate acyl-ACP transferase from Alistipes finegoldii | 分子名称: | 7-keto-8-aminopelargonate synthetase-like enzyme, PYRIDOXAL-5'-PHOSPHATE | 著者 | Radka, C.D, Miller, D.J, Frank, M.W, Rock, C.O. | 登録日 | 2022-03-07 | 公開日 | 2023-01-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii. J.Biol.Chem., 298, 2022
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8GFA
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![BU of 8gfa by Molmil](/molmil-images/mine/8gfa) | Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 | 分子名称: | (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2023-03-07 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | 主引用文献 | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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