7TCI
 
 | | Structure of Xenopus KCNQ1-CaM in complex with ML277 | | 分子名称: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, CALCIUM ION, Calmodulin-1, ... | | 著者 | Willegems, K, Kyriakis, E, Van Petegem, F, Eldstrom, J, Fedida, D. | | 登録日 | 2021-12-23 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Nat Commun, 13, 2022
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1TH1
 | | Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment | | 分子名称: | Adenomatous polyposis coli protein, Beta-catenin | | 著者 | Xing, Y, Clements, W.K, Le Trong, I, Hinds, T.R, Stenkamp, R, Kimelman, D, Xu, W. | | 登録日 | 2004-05-31 | | 公開日 | 2004-09-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of a beta-Catenin/APC Complex Reveals a Critical Role for APC Phosphorylation in APC Function.
Mol.Cell, 15, 2004
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7TCP
 | | Structure of Xenopus KCNQ1-CaM | | 分子名称: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | 著者 | Willegems, K, Kyriakis, E, Van Petegem, F, Eldstrom, J, Fedida, D. | | 登録日 | 2021-12-27 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Nat Commun, 13, 2022
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4RWL
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3EXX
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3EZ8
 | | Crystal Structure of endoglucanase Cel9A from the thermoacidophilic Alicyclobacillus acidocaldarius | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Cellulase, ... | | 著者 | Pereira, J.H, Sapra, R, Simmons, B, Adams, P.D. | | 登録日 | 2008-10-22 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Structure of endoglucanase Cel9A from the thermoacidophilic Alicyclobacillus acidocaldarius
Acta Crystallogr.,Sect.D, 65, 2009
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3EWZ
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6J2H
 | | Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 mutant (Met52 Asp53 Leu54 deleted) in complex with Hendra virus-derived peptide HeV1 | | 分子名称: | Beta-2-microglobulin, HeV1, Ptal-N*01:01 (Met52 Asp53 Leu54 deleted) | | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | | 登録日 | 2019-01-01 | | 公開日 | 2019-09-18 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.
Plos Biol., 17, 2019
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1TLS
 | | THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE | | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, THYMIDYLATE SYNTHASE | | 著者 | Hyatt, D.C, Maley, F, Montfort, W.R. | | 登録日 | 1996-12-03 | | 公開日 | 1997-07-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Biochemistry, 36, 1997
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7T5W
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1T0I
 | | YLR011wp, a Saccharomyces cerevisiae NA(D)PH-dependent FMN reductase | | 分子名称: | CALCIUM ION, FLAVIN MONONUCLEOTIDE, YLR011wp | | 著者 | Liger, D, Graille, M, Zhou, C.-Z, Leulliot, N, Quevillon-Cheruel, S, Blondeau, K, Janin, J, van Tilbeurgh, H. | | 登録日 | 2004-04-09 | | 公開日 | 2004-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure and Functional Characterization of Yeast YLR011wp, an Enzyme with NAD(P)H-FMN and Ferric Iron Reductase Activities
J.Biol.Chem., 279, 2004
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7SVQ
 | | Crystal Structure of L-galactose dehydrogenase from Spinacia oleracea in complex with NAD+ | | 分子名称: | L-galactose dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Santillan, J.A.V, Cabrejos, D.A.L, Pereira, H.M, Gomez, J.C.C, Garratt, R.C. | | 登録日 | 2021-11-19 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Characterization of L-Galactose Dehydrogenase: An Essential Enzyme for Vitamin C Biosynthesis.
Plant Cell.Physiol., 63, 2022
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6J2F
 | | Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV2 | | 分子名称: | HeV2, Ptal-N*01:01, beta-2 microglobulin | | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | | 登録日 | 2019-01-01 | | 公開日 | 2019-09-18 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.
Plos Biol., 17, 2019
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6IX2
 | | Structure of the A214C/A250I mutant of an epoxide hydrolase from Aspergillus usamii E001 (AuEH2) at 1.48 Angstroms resolution | | 分子名称: | GLYCEROL, Microsomal epoxide hyddrolase | | 著者 | Hu, D, Hu, B.C, Hou, X.D, Rao, Y.J, Wu, M.C. | | 登録日 | 2018-12-09 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.478 Å) | | 主引用文献 | Structure-Guided Regulation in the Enantioselectivity of an Epoxide Hydrolase to Produce Enantiomeric Monosubstituted Epoxides and Vicinal Diols via Kinetic Resolution.
Org.Lett., 24, 2022
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4QU3
 | | GES-2 ertapenem acyl-enzyme complex | | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase GES-2, ... | | 著者 | Stewart, N.K, Smith, C.A, Frase, H, Black, D.J, Vakulenko, S.B. | | 登録日 | 2014-07-10 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.402 Å) | | 主引用文献 | Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type beta-Lactamases.
Biochemistry, 54, 2015
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4QVC
 | | E.coli Hfq in complex with RNA Aus | | 分子名称: | RNA (5'-R(*AP*U*AP*AP*CP*UP*A)-3'), RNA-binding protein Hfq | | 著者 | Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. | | 登録日 | 2014-07-14 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq
Nucleic Acids Res., 43, 2015
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3EKH
 | | Calcium-saturated GCaMP2 T116V/K378W mutant monomer | | 分子名称: | CALCIUM ION, GLYCEROL, Myosin light chain kinase, ... | | 著者 | Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R. | | 登録日 | 2008-09-19 | | 公開日 | 2008-12-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
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4QXQ
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3EOC
 | | Cdk2/CyclinA complexed with a imidazo triazin-2-amine | | 分子名称: | 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine, Cell division protein kinase 2, Cyclin-A2 | | 著者 | Cheung, M, Kuntz, K, Pobanz, M, Salovich, J, Wilson, B, Andrews, W, Shewchuk, L, Epperly, A, Hassler, D, Leesnitzer, M, Smith, J, Smith, G, Lansing, T, Mook, R. | | 登録日 | 2008-09-26 | | 公開日 | 2008-11-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
Bioorg.Med.Chem.Lett., 18, 2008
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5D8A
 | | Crystal structure of recombinant foot-and-mouth-disease virus A22-H2093F empty capsid | | 分子名称: | VP1, VP2, VP3, ... | | 著者 | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | | 登録日 | 2015-08-16 | | 公開日 | 2015-09-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
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2IA4
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6VQU
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8PTF
 | | The surface-exposed lipo-protein of BtuG2 in complex with cyanocobalamin. | | 分子名称: | COB(II)INAMIDE, SODIUM ION, YncE family protein, ... | | 著者 | Whittaker, J, Felices Martinez, J.M, Guskov, A, Slotboom, D.J. | | 登録日 | 2023-07-14 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The surface-exposed lipo-protein of BtuG1 in complex with cyanocobinamide.
To Be Published
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6PGI
 | | Asymmetric functions of a binuclear metal cluster within the transport pathway of the ZIP transition metal transporters | | 分子名称: | BbZIP, CADMIUM ION | | 著者 | Zhang, T, Sui, D, Zhang, C, Logan, T, Hu, J. | | 登録日 | 2019-06-24 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.
Faseb J., 34, 2020
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5DFB
 | | Crystal structure of BRD2(BD2) mutant W370F in the free form | | 分子名称: | Bromodomain-containing protein 2, GLYCEROL, NICKEL (II) ION, ... | | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | | 登録日 | 2015-08-26 | | 公開日 | 2015-11-11 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.
J.Med.Chem., 59, 2016
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