4QXQ

Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA

Summary for 4QXQ

• Entry DOI: 10.2210/pdb4qxq/pdb
• Related: 4QXO 4QXP 4QXR
• Descriptor: Stimulator of interferon genes protein, (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: immune system, innate immunity, cgamp binding, membrane
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6
• Total number of polymer chains: 2
• Total formula weight: 43685.11

Authors

Gao, P.,Patel, D.J. (deposition date: 2014-07-21, release date: 2014-09-10, Last modification date: 2024-02-28)

• Primary citation: Gao, P.,Zillinger, T.,Wang, W.,Ascano, M.,Dai, P.,Hartmann, G.,Tuschl, T.,Deng, L.,Barchet, W.,Patel, D.J.; Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.; Cell Rep, 8:1668-1676, 2014; PubMed: 25199835; DOI: 10.1016/j.celrep.2014.08.010

Experimental method

X-RAY DIFFRACTION (2.42 Å)