4QXQ
Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Stimulator of interferon genes protein | polymer | 188 | 21512.2 | 2 | UniProt (Q86WV6) Pfam (PF15009) In PDB | Homo sapiens (human) | hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173 |
| 2 | A, B | (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid | non-polymer | 282.3 | 2 | Chemie (1YE) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ser 154 | - | expression tag |
| Ala 162 | Ser 162 | engineered mutation |
| Arg 232 | His 232 | engineered mutation |
| Ile 266 | Gln 266 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43024.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 660.6 | |
| All* | Total formula weight | 43685.1 |
