4QXO

Crystal structure of hSTING(group2) in complex with DMXAA

Summary for 4QXO

Entry DOI	10.2210/pdb4qxo/pdb
Related	4QXP 4QXQ 4QXR
Descriptor	Stimulator of interferon genes protein, (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid (3 entities in total)
Functional Keywords	immune system, innate immunity, cgamp binding, membrane
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6
Total number of polymer chains	1
Total formula weight	21925.64
Authors	Gao, P.,Patel, D.J. (deposition date: 2014-07-21, release date: 2014-09-10, Last modification date: 2024-02-28)
Primary citation	Gao, P.,Zillinger, T.,Wang, W.,Ascano, M.,Dai, P.,Hartmann, G.,Tuschl, T.,Deng, L.,Barchet, W.,Patel, D.J. Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA. Cell Rep, 8:1668-1676, 2014 Cited by PubMed: 25199835 DOI: 10.1016/j.celrep.2014.08.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation