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4QXO

Crystal structure of hSTING(group2) in complex with DMXAA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AStimulator of interferon genes proteinpolymer18821643.31UniProt (Q86WV6)
Pfam (PF15009)
In PDB
Homo sapiens (human)hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173
2A(5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acidnon-polymer282.31Chemie (1YE)
3waterwater18.0134Chemie (HOH)
Sequence modifications
A: 155 - 341 (UniProt: Q86WV6)
PDBExternal DatabaseDetails
Ser 154-expression tag
Arg 222Leu 222engineered mutation
Met 224Lys 224engineered mutation
Asn 229Thr 229engineered mutation
Ile 230Gly 230engineered mutation
Arg 232His 232engineered mutation
Asn 237Asp 237engineered mutation
Val 244Ile 244engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight21643.3
Non-Polymers*Number of molecules1
Total formula weight282.3
All*Total formula weight21925.6
*Water molecules are not included.

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PDB entries from 2024-07-17

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