4QXO
Crystal structure of hSTING(group2) in complex with DMXAA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stimulator of interferon genes protein | polymer | 188 | 21643.3 | 1 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173 |
| 2 | B (A) | (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid | non-polymer | 282.3 | 1 | Chemie (1YE) | |||
| 3 | C (A) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A: 155 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ser 154 | - | expression tag |
| Arg 222 | Leu 222 | engineered mutation |
| Met 224 | Lys 224 | engineered mutation |
| Asn 229 | Thr 229 | engineered mutation |
| Ile 230 | Gly 230 | engineered mutation |
| Arg 232 | His 232 | engineered mutation |
| Asn 237 | Asp 237 | engineered mutation |
| Val 244 | Ile 244 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21643.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 282.3 | |
| All* | Total formula weight | 21925.6 |
