4QU3

GES-2 ertapenem acyl-enzyme complex

Summary for 4QU3

• Entry DOI: 10.2210/pdb4qu3/pdb
• Related: 3NI9 3NIA
• Descriptor: Beta-lactamase GES-2, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: antibiotic resistance, beta-lactamase, hydrolase, ertapenem, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 64317.61

Authors

Stewart, N.K.,Smith, C.A.,Frase, H.,Black, D.J.,Vakulenko, S.B. (deposition date: 2014-07-10, release date: 2014-12-31, Last modification date: 2023-09-20)

• Primary citation: Stewart, N.K.,Smith, C.A.,Frase, H.,Black, D.J.,Vakulenko, S.B.; Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type beta-Lactamases.; Biochemistry, 54:588-597, 2015; PubMed: 25485972; DOI: 10.1021/bi501052t

Experimental method

X-RAY DIFFRACTION (1.402 Å)