7TCI

Structure of Xenopus KCNQ1-CaM in complex with ML277

Summary for 7TCI

• Entry DOI: 10.2210/pdb7tci/pdb
• EMDB information: 25813 25816
• Descriptor: Potassium voltage-gated channel subfamily KQT member 1, Calmodulin-1, (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: activator, ion channel, transport protein-activator complex, transport protein/activator
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 8
• Total formula weight: 320431.08

Authors

Willegems, K.,Kyriakis, E.,Van Petegem, F.,Eldstrom, J.,Fedida, D. (deposition date: 2021-12-23, release date: 2022-07-06, Last modification date: 2024-02-28)

• Primary citation: Willegems, K.,Eldstrom, J.,Kyriakis, E.,Ataei, F.,Sahakyan, H.,Dou, Y.,Russo, S.,Van Petegem, F.,Fedida, D.; Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.; Nat Commun, 13:3760-3760, 2022; PubMed: 35768468; DOI: 10.1038/s41467-022-31526-7

Experimental method

ELECTRON MICROSCOPY (3.9 Å)