7TCI
Structure of Xenopus KCNQ1-CaM in complex with ML277
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, E, C, G) | Potassium voltage-gated channel subfamily KQT member 1 | polymer | 548 | 62663.4 | 4 | UniProt (P70057) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520) | Xenopus laevis (African clawed frog) | IKs producing slow voltage-gated potassium channel subunit alpha xKvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, KCNQ1 |
| 2 | B, D, F, H (B, F, D, H) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | I, M, Q, U (A, E, C, G) | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide | non-polymer | 471.6 | 4 | Chemie (I0S) | |||
| 4 | J, K, L, N, O... (B, F, D, H) | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) |
Sequence modifications
A, E, C, G: 67 - 610 (UniProt: P70057)
| PDB | External Database | Details |
|---|---|---|
| Met 66 | - | initiating methionine |
| Ser 611 | - | expression tag |
| Asn 612 | - | expression tag |
| Ser 613 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 318063.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2367.3 | |
| All* | Total formula weight | 320431.1 |
