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1TLS

THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE

Summary for 1TLS
Entry DOI10.2210/pdb1tls/pdb
DescriptorTHYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, ... (4 entities in total)
Functional Keywordstransferase, methyltransferase
Biological sourceEscherichia coli
Total number of polymer chains2
Total formula weight62690.59
Authors
Hyatt, D.C.,Maley, F.,Montfort, W.R. (deposition date: 1996-12-03, release date: 1997-07-07, Last modification date: 2021-03-10)
Primary citationHyatt, D.C.,Maley, F.,Montfort, W.R.
Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Biochemistry, 36:4585-4594, 1997
Cited by
PubMed: 9109668
DOI: 10.1021/bi962936j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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