5NG0
 
 | | Structure of RIP2K(L294F) with bound AMPPCP | | Descriptor: | COBALT (II) ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Pellegrini, E, Cusack, S. | | Deposit date: | 2017-03-16 | | Release date: | 2017-06-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
PLoS ONE, 12, 2017
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5FO4
 | | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) | | Descriptor: | LEUCYL TRNA SYNTHASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-18 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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5FOD
 | | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) containing deletions of insertions 1 and 3 | | Descriptor: | 1,2-ETHANEDIOL, LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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5FOC
 | | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21) | | Descriptor: | LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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5FOF
 | | Crystal structure of the P.knowlesi cytosolic leucyl-tRNA synthetase editing domain | | Descriptor: | LEUCYL-TRNA SYNTHETASE | | Authors: | Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. | | Deposit date: | 2015-11-19 | | Release date: | 2016-06-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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2BSY
 | | Epstein Barr Virus dUTPase | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, SULFATE ION | | Authors: | Tarbouriech, N, Buisson, M, Seigneurin, J.-M, Cusack, S, Burmeister, W.P. | | Deposit date: | 2005-05-24 | | Release date: | 2005-09-15 | | Last modified: | 2023-03-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The Monomeric Dutpase from Epstein-Barr Virus Mimics Trimeric Dutpases
Structure, 13, 2005
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5FMM
 | | crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza a virus polymerase PB2 subunit bound to M7GTP | | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CITRATE ANION, INFLUENZA A PB2 SUBUNIT | | Authors: | Thierry, E, Pflug, A, Hart, D, Cusack, S. | | Deposit date: | 2015-11-06 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
Mol.Cell, 61, 2016
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5FMQ
 | | Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form | | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, INFLUENZA A PB2 SUBUNIT | | Authors: | Thierry, E, Pflug, A, Hart, D, Cusack, S. | | Deposit date: | 2015-11-07 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
Mol.Cell, 61, 2016
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2B1W
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5OMW
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5ONH
 | | Quaternary complex of wild type E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of norvaline in the aminoacylation conformation | | Descriptor: | 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, L-leucyl-tRNA(Leu), ... | | Authors: | Palencia, A, Cusack, S. | | Deposit date: | 2017-08-03 | | Release date: | 2017-11-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
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2C6S
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2BT1
 | | Epstein Barr Virus dUTPase in complex with a,b-imino dUTP | | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MAGNESIUM ION | | Authors: | Tarbouriech, N, Buisson, M, Seigneurin, J.-M, Cusack, S, Burmeister, W.P. | | Deposit date: | 2005-05-24 | | Release date: | 2005-09-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The Monomeric Dutpase from Epstein-Barr Virus Mimics Trimeric Dutpases
Structure, 13, 2005
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1H7Z
 | | Adenovirus Ad3 fibre head | | Descriptor: | ADENOVIRUS FIBRE PROTEIN, SULFATE ION | | Authors: | Durmort, C, Stehlin, C, Schoehn, G, Mitraki, A, Drouet, E, Cusack, S, Burmeister, W.P. | | Deposit date: | 2001-01-21 | | Release date: | 2001-07-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the Fiber Head of Ad3, a Non-Car-Binding Serotype of Adenovirus
Virology, 285, 2001
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5ON2
 | | Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of norvaline in the aminoacylation conformation | | Descriptor: | 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | | Authors: | Palencia, A, Cusack, S. | | Deposit date: | 2017-08-02 | | Release date: | 2017-11-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
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2BZV
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2BZU
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7ORJ
 | | La Crosse virus polymerase at transcription capped RNA cleavage stage | | Descriptor: | 5' capped RNA, ADENOSINE-5'-TRIPHOSPHATE, RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORI
 | | La Crosse virus polymerase at replication late-elongation stage | | Descriptor: | La Crosse virus polymerase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORN
 | | La Crosse virus polymerase at replication initiation stage | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, La Crosse virus polymerase, MAGNESIUM ION, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORL
 | | La Crosse virus polymerase at transcription initiation stage | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORM
 | | La Crosse virus polymerase at transcription early-elongation stage | | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORK
 | | La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (5'-D(*(GTG))-R(P*A)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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5AMR
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5AMQ
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