5FOD

Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) containing deletions of insertions 1 and 3

Summary for 5FOD

• Entry DOI: 10.2210/pdb5fod/pdb
• Related: 5FO4 5FOC 5FOF 5FOG 5FOL 5FOM 5FON
• Descriptor: LEUCYL-TRNA SYNTHETASE, 1,2-ETHANEDIOL (3 entities in total)
• Functional Keywords: ligase, p.falciparum, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) gives amp + diphosphate + l-leucyl-trna(leucine), aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs
• Biological source: PLASMODIUM FALCIPARUM
• Total number of polymer chains: 2
• Total formula weight: 79728.77

Authors

Palencia, A.,Sonoiki, E.,Guo, D.,Ahyong, V.,Dong, C.,Li, X.,Hernandez, V.S.,Gut, J.,Legac, J.,Cooper, R.,Alley, M.R.K.,Freund, Y.R.,DeRisi, J.,Cusack, S.,Rosenthal, P.J. (deposition date: 2015-11-19, release date: 2016-06-22, Last modification date: 2017-09-27)

• Primary citation: Sonoiki, E.,Palencia, A.,Guo, D.,Ahyong, V.,Dong, C.,Li, X.,Hernandez, V.S.,Zhang, Y.K.,Choi, W.,Gut, J.,Legac, J.,Cooper, R.,Alley, M.R.,Freund, Y.R.,Derisi, J.,Cusack, S.,Rosenthal, P.J.; Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.; Antimicrob.Agents Chemother., 60:4886-, 2016; PubMed: 27270277; DOI: 10.1128/AAC.00820-16

Experimental method

X-RAY DIFFRACTION (1.7 Å)