5FOC
Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21)
Summary for 5FOC
Entry DOI | 10.2210/pdb5foc/pdb |
Related | 5FO4 5FOD 5FOF 5FOG 5FOL 5FOM 5FON |
Descriptor | LEUCYL-TRNA SYNTHETASE (2 entities in total) |
Functional Keywords | ligase, p.falciparum, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) gives amp + diphosphate + l-leucyl-trna(leucine), aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs |
Biological source | PLASMODIUM FALCIPARUM |
Total number of polymer chains | 2 |
Total formula weight | 86705.96 |
Authors | Palencia, A.,Sonoiki, E.,Guo, D.,Ahyong, V.,Dong, C.,Li, X.,Hernandez, V.S.,Gut, J.,Legac, J.,Cooper, R.,Alley, M.R.K.,Freund, Y.R.,DeRisi, J.,Cusack, S.,Rosenthal, P.J. (deposition date: 2015-11-19, release date: 2016-06-22, Last modification date: 2024-05-01) |
Primary citation | Sonoiki, E.,Palencia, A.,Guo, D.,Ahyong, V.,Dong, C.,Li, X.,Hernandez, V.S.,Zhang, Y.K.,Choi, W.,Gut, J.,Legac, J.,Cooper, R.,Alley, M.R.,Freund, Y.R.,Derisi, J.,Cusack, S.,Rosenthal, P.J. Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60:4886-, 2016 Cited by PubMed: 27270277DOI: 10.1128/AAC.00820-16 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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