5FOF

Crystal structure of the P.knowlesi cytosolic leucyl-tRNA synthetase editing domain

Summary for 5FOF

Entry DOI	10.2210/pdb5fof/pdb
Related	5FO4 5FOC 5FOD 5FOG 5FOL 5FOM 5FON
Descriptor	LEUCYL-TRNA SYNTHETASE (2 entities in total)
Functional Keywords	ligase, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) gives amp + diphosphate + l-leucyl-trna(leucine), aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs
Biological source	PLASMODIUM KNOWLESI
Total number of polymer chains	4
Total formula weight	155293.16
Authors	Palencia, A.,Sonoiki, E.,Guo, D.,Ahyong, V.,Dong, C.,Li, X.,Hernandez, V.S.,Gut, J.,Legac, J.,Cooper, R.,Alley, M.R.K.,Freund, Y.R.,DeRisi, J.,Cusack, S.,Rosenthal, P.J. (deposition date: 2015-11-19, release date: 2016-06-22, Last modification date: 2016-08-10)
Primary citation	Sonoiki, E.,Palencia, A.,Guo, D.,Ahyong, V.,Dong, C.,Li, X.,Hernandez, V.S.,Zhang, Y.K.,Choi, W.,Gut, J.,Legac, J.,Cooper, R.,Alley, M.R.,Freund, Y.R.,Derisi, J.,Cusack, S.,Rosenthal, P.J. Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60:4886-, 2016 Cited by PubMed: 27270277 DOI: 10.1128/AAC.00820-16 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation