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PDB: 197 件
3KR8
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Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939
分子名称: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, SULFATE ION, ...
著者Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-11-18
公開日2009-12-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.
J.Med.Chem., 53, 2010
6GDI
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Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state
分子名称: Multidrug resistance protein 1A
著者Ford, R.C, Thonghin, N, Collins, R.F, Barbieri, A, Shafi, T, Siebert, A.
登録日2018-04-23
公開日2018-05-23
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (7.9 Å)
主引用文献Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution.
Bmc Struct.Biol., 18, 2018
1UWX
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P1.2 serosubtype antigen derived from N. meningitidis PorA in complex with Fab fragment
分子名称: ANTIBODY, CLASS 1 OUTER MEMBRANE PROTEIN VARIABLE REGION 2, PROTEIN G-PRIME
著者Tzitzilonis, C, Prince, S.M, Collins, R.F, Maiden, M.C.J, Feavers, I.M, Derrick, J.P.
登録日2004-02-12
公開日2005-06-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Variation and Immune Recognition of the P1.2 Subtype Meningococcal Antigen.
Proteins: Struct., Funct., Bioinf., 62, 2005
1U2Z
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Crystal structure of histone K79 methyltransferase Dot1p from yeast
分子名称: Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE
著者Sawada, K, Yang, Z, Horton, J.R, Collins, R.E, Zhang, X, Cheng, X.
登録日2004-07-20
公開日2004-09-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase
J.Biol.Chem., 279, 2004
1PZD
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Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.
分子名称: Coatomer gamma subunit, SULFATE ION
著者Hoffman, G.R, Rahl, P.B, Collins, R.N, Cerione, R.A.
登録日2003-07-10
公開日2003-10-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Conserved Structural Motifs in Intracellular Trafficking Pathways. Structure of the gammaCOP Appendage Domain.
Mol.Cell, 12, 2003
1OW9
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NMR Structure of the Active Conformation of the VS Ribozyme Cleavage Site
分子名称: A mimic of the VS Ribozyme Hairpin Substrate
著者Hoffmann, B, Mitchell, G.T, Gendron, P, Major, F, Andersen, A.A, Collins, R.A, Legault, P.
登録日2003-03-28
公開日2003-05-20
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献NMR Structure of the Active Conformation of the Varkud satellite Ribozyme Cleavage Site
Proc.Natl.Acad.Sci.USA, 100, 2003
4IRU
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Crystal Structure of lepB GAP core in a transition state mimetic complex with Rab1A and ALF3
分子名称: ACETATE ION, ALUMINUM FLUORIDE, GLYCEROL, ...
著者Mishra, A.K, Delcampo, C.M, Collins, R.E, Roy, C.R, Lambright, D.G.
登録日2013-01-15
公開日2013-07-10
最終更新日2013-09-04
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism.
J.Biol.Chem., 288, 2013
3GVP
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Human SAHH-like domain of human adenosylhomocysteinase 3
分子名称: Adenosylhomocysteinase 3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Siponen, M.I, Wisniewska, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schueler, H.
登録日2009-03-31
公開日2009-06-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure
To be Published
3IQ2
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Human sorting nexin 7, phox homology (PX) domain
分子名称: GLYCEROL, SULFATE ION, Sorting nexin-7
著者Karlberg, T, Wisniewska, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-08-19
公開日2009-09-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Human Sorting Nexin 7, Phox Homology (Px) Domain
To be Published
3IHY
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Human PIK3C3 crystal structure
分子名称: Phosphatidylinositol 3-kinase catalytic subunit type 3
著者Siponen, M.I, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Moche, M, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2009-07-31
公開日2009-10-13
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human PIK3C3 crystal structure
TO BE PUBLISHED
3IHL
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Human CTPS2 crystal structure
分子名称: ADENOSINE-5'-DIPHOSPHATE, CTP synthase 2, PHOSPHATE ION
著者Moche, M, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2009-07-30
公開日2009-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human CTPS2 crystal structure
To be Published
3I35
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Human SH3 domain of protein LASP1
分子名称: LIM and SH3 domain protein 1
著者Siponen, M.I, Roos, A.K, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Moche, M, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2009-06-30
公開日2009-09-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Human SH3 domain of protein LASP1
TO BE PUBLISHED
3IHJ
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Human alanine aminotransferase 2 in complex with PLP
分子名称: Alanine aminotransferase 2, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE
著者Wisniewska, M, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-07-30
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human glutamate pyruvate transaminase 2
To be Published
3GZD
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Human selenocysteine lyase, P1 crystal form
分子名称: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, NITRATE ION, Selenocysteine lyase
著者Karlberg, T, Hogbom, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-04-07
公開日2009-04-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.
Plos One, 7, 2012
3K2I
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Human Acyl-coenzyme A thioesterase 4
分子名称: Acyl-coenzyme A thioesterase 4, CHLORIDE ION, NICKEL (II) ION
著者Siponen, M.I, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kraulis, P, Kotenyova, T, Kotzsch, A, Markova, N, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-09-30
公開日2009-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Human Acyl-coenzyme A thioesterase 4
To be Published
3H95
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Crystal structure of the NUDIX domain of NUDT6
分子名称: CITRATE ANION, GLYCEROL, Nucleoside diphosphate-linked moiety X motif 6
著者Tresaugues, L, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotyenova, T, Kotzch, A, Nielsen, T.K, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2009-04-30
公開日2009-07-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of the NUDIX domain of NUDT6
To be Published
4Z8Y
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BU of 4z8y by Molmil
Crystal structure of Rab GTPase Sec4p mutant - S29V
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein SEC4, ...
著者Rinadi, F.C, Collins, R.N.
登録日2015-04-09
公開日2015-10-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Bmc Struct.Biol., 15, 2015
2OJW
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Crystal structure of human glutamine synthetase in complex with ADP and phosphate
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
著者Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2007-01-15
公開日2007-03-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
2NZ2
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Crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline
分子名称: ASPARTIC ACID, Argininosuccinate synthase, CITRULLINE, ...
著者Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Magnusdottir, A, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2006-11-22
公開日2006-12-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of human argininosuccinate synthetase.
Acta Crystallogr.,Sect.D, 64, 2008
2ODT
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Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase
分子名称: Inositol-tetrakisphosphate 1-kinase
著者Busam, R.D, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Hammarstrom, M, Holmberg, S.L, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Sagemark, J, Sundstrom, M, Uppenberg, J, Van Den Berg, S, Weigelt, J, Persson, C, Thorsell, A.G, Hallberg, B.M, Structural Genomics Consortium (SGC)
登録日2006-12-26
公開日2007-02-13
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase
To be Published
3IUY
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Crystal structure of DDX53 DEAD-box domain
分子名称: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, Probable ATP-dependent RNA helicase DDX53
著者Schutz, P, Karlberg, T, Collins, R, Arrowsmith, C.H, Berglund, H, Bountra, C, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kraulis, P, Kotenyova, T, Kotzsch, A, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H.M, Structural Genomics Consortium (SGC)
登録日2009-08-31
公開日2009-10-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Comparative Structural Analysis of Human DEAD-Box RNA Helicases.
Plos One, 5, 2010
4ZDW
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Crystal structure of the Rab GTPase Sec4p mutant - S29V in complex with Sec2p and GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, Rab guanine nucleotide exchange factor SEC2, Ras-related protein SEC4
著者Rinadi, F.C, Collins, R.N.
登録日2015-04-20
公開日2015-10-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Bmc Struct.Biol., 15, 2015
2NMP
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Crystal structure of human Cystathionine gamma lyase
分子名称: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
著者Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Magnusdottir, A, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van-den-Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2006-10-23
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
2OXC
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Human DEAD-box RNA helicase DDX20, DEAD domain in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Probable ATP-dependent RNA helicase DDX20
著者Karlberg, T, Ogg, D, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Lehtio, L, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2007-02-20
公開日2007-02-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Human DEAD-box RNA helicase DDX20
To be Published
3HKV
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Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide
分子名称: 3-aminobenzamide, PHOSPHATE ION, Poly [ADP-ribose] polymerase 10, ...
著者Karlberg, T, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Kotzsch, A, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
登録日2009-05-26
公開日2009-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human Poly(Adp-Ribose) Polymerase 10, Catalytic Fragment in Complex with an Inhibitor 3-Aminobenzamide
To be Published

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