3KR8

Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939

Summary for 3KR8

• Entry DOI: 10.2210/pdb3kr8/pdb
• Related: 3KR7
• Descriptor: Tankyrase-2, ZINC ION, 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ... (6 entities in total)
• Functional Keywords: catalytic fragment, parp, structural genomics, structural genomics consortium, sgc, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, golgi apparatus, membrane, mrna transport, nad, nuclear pore complex, nucleus, phosphorylation, protein transport, telomere, transferase, translocation, transport, wnt-signalling, xav939
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 55923.41

Authors

Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Kotzsch, A.,Kraulis, P.,Nielsen, T.K.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Siponen, M.I.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-11-18, release date: 2009-12-15, Last modification date: 2023-11-01)

• Primary citation: Karlberg, T.,Markova, N.,Johansson, I.,Hammarstrom, M.,Schutz, P.,Weigelt, J.,Schuler, H.; Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.; J.Med.Chem., 53:5352-5355, 2010; PubMed: 20565110; DOI: 10.1021/jm100249w

Experimental method

X-RAY DIFFRACTION (2.1 Å)