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PDB: 51 件
1ECM
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BU of 1ecm by Molmil
ATOMIC STRUCTURE OF THE BURIED CATALYTIC POCKET OF ESCHERICHIA COLI CHORISMATE MUTASE
分子名称: 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID, ENDO-OXABICYCLIC TRANSITION STATE ANALOGUE
著者Clardy, J, Lee, A.Y.
登録日1994-11-28
公開日1995-12-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献ATOMIC-STRUCTURE OF THE BURIED CATALYTIC POCKET OF ESCHERICHIA-COLI CHORISMATE MUTASE.
J.Am.Chem.Soc., 117, 1995
2B0M
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BU of 2b0m by Molmil
Human dihydroorotate dehydrogenase bound to a novel inhibitor
分子名称: 3-AMIDO-5-BIPHENYL-BENZOIC ACID, Dihydroorotate dehydrogenase, mitochondrial, ...
著者Hurt, D.E, Sutton, A.E, Clardy, J.
登録日2005-09-14
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Bioorg.Med.Chem.Lett., 16, 2006
3FAP
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BU of 3fap by Molmil
ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
分子名称: C15-(R)-METHYLTHIENYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN
著者Liang, J, Clardy, J.
登録日1999-05-06
公開日2000-09-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
4FAP
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ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
分子名称: C15-(R)-METHYLTHIENYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN
著者Liang, J, Clardy, J.
登録日1999-05-06
公開日2000-09-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
4NNR
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BU of 4nnr by Molmil
FKBP13-FK506 Complex
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP2
著者Schultz, L.W, Martin, P.K, Liang, J, Schreiber, S.L, Clardy, J.
登録日2013-11-18
公開日2014-02-05
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Atomic structure of the Immunophilin FKBP13-FK506 Complex: Insights into the Composite Binding Surface for Calcineurin
J.Am.Chem.Soc., 116, 1994
3OGN
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BU of 3ogn by Molmil
Crystal Structure of an Odorant-binding Protein from the Southern House Mosquito Complexed with an Oviposition Pheromone
分子名称: (1S)-1-[(2R)-6-oxotetrahydro-2H-pyran-2-yl]undecyl acetate, MAGNESIUM ION, Odorant-binding protein
著者Mao, Y, Clardy, J.
登録日2010-08-17
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone.
Proc.Natl.Acad.Sci.USA, 107, 2010
2FAP
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THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA
分子名称: C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FRAP
著者Liang, J, Choi, J, Clardy, J.
登録日1998-09-22
公開日1999-05-18
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
2NGR
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TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP.
分子名称: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Nassar, N, Hoffman, G, Clardy, J, Cerione, R.
登録日1998-07-31
公開日1999-01-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nat.Struct.Biol., 5, 1998
1PBK
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BU of 1pbk by Molmil
HOMOLOGOUS DOMAIN OF HUMAN FKBP25
分子名称: FKBP25, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
著者Liang, J, Hung, D.T, Schreiber, S.L, Clardy, J.
登録日1995-09-01
公開日1996-10-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the human 25 kDa FK506 binding protein complexed with rapamycin.
J.Am.Chem.Soc., 118, 1996
1PHT
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PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85
分子名称: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT
著者Liang, J, Chen, J.K, Schreiber, S.L, Clardy, J.
登録日1995-08-17
公開日1995-12-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of P13K SH3 domain at 20 angstroms resolution.
J.Mol.Biol., 257, 1996
2P71
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Bombyx mori pheromone binding protein bound to iodohexadecane
分子名称: 1-IODOHEXADECANE, pheromone-binding protein
著者Lautenschlager, C.L, Clardy, J.
登録日2007-03-19
公開日2007-04-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition.
Structure, 15, 2007
2P70
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Bombyx mori pheromone binding protein bound to bell pepper odorant
分子名称: 2-ISOBUTYL-3-METHOXYPYRAZINE, pheromone-binding protein
著者Lautenschlager, C.L, Clardy, J.
登録日2007-03-19
公開日2007-04-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition.
Structure, 15, 2007
1TV5
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Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor
分子名称: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Dihydroorotate dehydrogenase homolog, ...
著者Hurt, D.E, Widom, J, Clardy, J.
登録日2004-06-27
公開日2005-09-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
1TYN
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BU of 1tyn by Molmil
ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS
分子名称: BETA-TRYPSIN, CYCLOTHEONAMIDE A
著者Lee, A.Y, Hagihara, M, Karmacharya, R, Albers, M.W, Schreiber, S.L, Clardy, J.
登録日1994-09-19
公開日1995-01-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Atomic Structure of the Trypsin-Cyclotheonamide a Complex: Lessons for the Design of Serine Protease Inhibitors
J.Am.Chem.Soc., 115, 1993
2MAI
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BU of 2mai by Molmil
NMR structure of lassomycin
分子名称: Lassomycin
著者Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K.
登録日2013-07-09
公開日2014-05-07
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2.
Chem.Biol., 21, 2014
2G0B
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BU of 2g0b by Molmil
The structure of FeeM, an N-acyl amino acid synthase from uncultured soil microbes
分子名称: FeeM, N-DODECANOYL-L-TYROSINE
著者Van Wagoner, R.M, Clardy, J.
登録日2006-02-11
公開日2006-09-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding.
Structure, 14, 2006
1PJA
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The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Palmitoyl-protein thioesterase 2 precursor
著者Calero, G, Gupta, P, Nonato, M.C, Tandel, S, Biehl, E.R, Hofmann, S.L, Clardy, J.
登録日2003-06-02
公開日2003-09-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.
J.Biol.Chem., 278, 2003
1TPS
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BU of 1tps by Molmil
ATOMIC STRUCTURE OF THE TRYPSIN-A90720A COMPLEX: A UNIFIED APPROACH TO STRUCTURE AND FUNCTION
分子名称: CALCIUM ION, INHIBITOR A90720A, TRYPSIN
著者Lee, A.Y, Clardy, J.
登録日1994-09-04
公開日1995-01-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function.
Chem.Biol., 1, 1994
2FJY
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BU of 2fjy by Molmil
Crystal Structure of B-form Bombyx mori Pheromone Binding Protein
分子名称: Pheromone-binding protein
著者Lautenschlager, C, Leal, W.S, Clardy, J.
登録日2006-01-03
公開日2006-01-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Coil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein.
Biochem.Biophys.Res.Commun., 335, 2005
1KT1
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BU of 1kt1 by Molmil
Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes
分子名称: FK506-binding protein FKBP51, SULFATE ION
著者Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C.
登録日2002-01-14
公開日2003-02-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献STRUCTURE OF THE LARGE FK506-BINDING PROTEIN FKBP51, AN HSP90-BINDING PROTEIN AND A COMPONENT OF STEROID RECEPTOR COMPLEXES
Proc.Natl.Acad.Sci.USA, 100, 2003
1NSG
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THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
分子名称: C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP)
著者Liang, J, Choi, J, Clardy, J.
登録日1997-07-01
公開日1998-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1N52
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Cap Binding Complex
分子名称: 20 kDa nuclear cap binding protein, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, 80 kDa nuclear cap binding protein, ...
著者Calero, G, Wilson, K, Ly, T, Rios-Steiner, J, Clardy, J, Cerione, R.
登録日2002-11-04
公開日2003-02-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
1N54
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Cap Binding Complex m7GpppG free
分子名称: 20 kDa nuclear cap binding protein, 80 kDa nuclear cap binding protein, GLYCEROL
著者Calero, G, Wilson, K, Ly, T, Rios-Steiner, J, Clardy, J, Cerione, R.
登録日2002-11-04
公開日2003-02-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
1FKH
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DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
分子名称: 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE, FK506 BINDING PROTEIN
著者Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J.
登録日1993-08-05
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
1FKI
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DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12
分子名称: (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE, FK506 BINDING PROTEIN
著者Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J.
登録日1993-08-05
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993

 

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