1FKH

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

Summary for 1FKH

Entry DOI	10.2210/pdb1fkh/pdb
Descriptor	FK506 BINDING PROTEIN, 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE (3 entities in total)
Functional Keywords	cis-trans isomerase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol : P62942
Total number of polymer chains	1
Total formula weight	12292.14
Authors	Holt, D.A.,Luengo, J.I.,Yamashita, D.S.,Oh, H.-J.,Konialian, A.L.,Yen, H.-K.,Rozamus, L.W.,Brandt, M.,Bossard, M.J.,Levy, M.A.,Eggleston, D.S.,Stout, T.J.,Liang, J.,Schultz, L.W.,Clardy, J. (deposition date: 1993-08-05, release date: 1994-01-31, Last modification date: 2024-02-07)
Primary citation	Holt, D.A.,Luengo, J.I.,Yamashita, D.S.,Oh, H.J.,Konialian, A.L.,Yen, H.K.,Rozamus, L.W.,Brandt, M.,Bossard, M.J.,Levy, M.A.,Eggleston, D.S.,Liang, J.,Schultz, L.W.,Stout, T.J.,Clardy, J. DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12. J.Am.Chem.Soc., 115:9925-9938, 1993 Cited by
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation