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PDB: 268 件
6XJT
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BU of 6xjt by Molmil
Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ)
分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6XJU
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BU of 6xju by Molmil
Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)
分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.193 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6XJS
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BU of 6xjs by Molmil
Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.942 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
3GB8
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BU of 3gb8 by Molmil
Crystal structure of CRM1/Snurportin-1 complex
分子名称: Exportin-1, Snurportin-1
著者Dong, X, Biswas, A, Suel, K.E, Jackson, L.K, Martinez, R, Gu, H, Chook, Y.M.
登録日2009-02-19
公開日2009-03-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for leucine-rich nuclear export signal recognition by CRM1.
Nature, 458, 2009
4A4D
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BU of 4a4d by Molmil
Crystal structure of the N-terminal domain of the Human DEAD-BOX RNA helicase DDX5 (P68)
分子名称: PROBABLE ATP-DEPENDENT RNA HELICASE DDX5
著者Dutta, S, Choi, Y.W, Kotaka, M, Fielding, B.C, Tan, Y.J.
登録日2011-10-11
公開日2012-08-08
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Variable N-Terminal Region of Ddx5 Contains Structural Elements and Auto-Inhibits its Interaction with Ns5B of Hepatitis C Virus.
Biochem.J., 446, 2012
8SGH
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BU of 8sgh by Molmil
Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS
分子名称: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1
著者Gonzalez, A, Fung, H.Y.J, Chook, Y.M.
登録日2023-04-12
公開日2023-06-14
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.
Structure, 31, 2023
2B1G
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BU of 2b1g by Molmil
Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
分子名称: 7-(3,4-DIHYDROXY-5R-HYDROXYMETHYLTETRAHYDROFURAN-2-YL)-2,2-DIOXO-1,2R,3R,7-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-4S-ONE, Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, ...
著者Xu, L, Chong, Y, Hwang, I, D'Onofrio, A, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A.
登録日2005-09-15
公開日2006-11-21
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
1LB4
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TRAF6 apo structure
分子名称: TNF receptor-associated factor 6
著者Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H.
登録日2002-04-02
公開日2002-07-31
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Distinct molecular mechanism for initiating TRAF6 signalling.
Nature, 418, 2002
1LB5
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TRAF6-RANK Complex
分子名称: TNF receptor-associated factor 6, receptor activator of nuclear factor-kappa B
著者Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H.
登録日2002-04-02
公開日2002-07-31
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Distinct molecular mechanism for initiating TRAF6 signalling.
Nature, 418, 2002
1LB6
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TRAF6-CD40 Complex
分子名称: CD40 antigen, TNF receptor-associated factor 6
著者Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H.
登録日2002-04-02
公開日2002-07-31
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Distinct molecular mechanism for initiating TRAF6 signalling.
Nature, 418, 2002
2B1I
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BU of 2b1i by Molmil
crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
分子名称: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
著者Xu, L, Chong, Y, Hwang, I, D'Onofrio, A, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A.
登録日2005-09-15
公開日2006-11-21
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
7E60
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BU of 7e60 by Molmil
The crystal structure of peptidoglycan peptidase in complex with inhibitor 1
分子名称: (2~{R},6~{S})-2,6-diacetamido-7-[[(2~{R})-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-7-oxidanylidene-heptanoic acid, Peptidase M23, ZINC ION
著者Min, K, Yoon, H.J, Choi, Y, Lee, H.H.
登録日2021-02-21
公開日2022-02-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structure-based inhibitor design for reshaping bacterial morphology
Commun Biol, 5, 2022
7E61
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BU of 7e61 by Molmil
The crystal structure of peptidoglycan peptidase in complex with inhibitor 2
分子名称: 2-[[(3S)-3-acetamido-4-[[(2R)-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-4-oxidanylidene-butyl]-(phenylmethyl)amino]ethanoic acid, Peptidase M23, ZINC ION
著者Min, K.J, Yoon, H.J, Choi, Y, Lee, H.H.
登録日2021-02-21
公開日2022-02-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-based inhibitor design for reshaping bacterial morphology
Commun Biol, 5, 2022
1U9Q
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BU of 1u9q by Molmil
Crystal structure of cruzain bound to an alpha-ketoester
分子名称: [1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER, cruzipain
著者Lange, M, Weston, S.G, Cheng, H, Culliane, M, Fiorey, M.M, Grisostomi, C, Hardy, L.W, Hartstough, D.S, Pallai, P.V, Tilton, R.F, Baldino, C.M, Brinen, L.S, Engel, J.C, Choe, Y, Price, M.S, Craik, C.S.
登録日2004-08-10
公開日2005-03-29
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease
Bioorg.Med.Chem., 13, 2005
8F19
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BU of 8f19 by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP)
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ...
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E
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BU of 8f1e by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ...
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F0X
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BU of 8f0x by Molmil
Cryo-EM structure of Kap114 bound to H2A-H2B
分子名称: Histone H2A.2, Histone H2B.2, Importin subunit beta-5
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.21 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8HST
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BU of 8hst by Molmil
The structure of rat beta-arrestin1
分子名称: Beta-arrestin-1
著者Yun, Y, Yoon, H.J, Choi, Y, Lee, H.H.
登録日2022-12-20
公開日2023-07-19
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献GPCR targeting of E3 ubiquitin ligase MDM2 by inactive beta-arrestin.
Proc.Natl.Acad.Sci.USA, 120, 2023
8HSV
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BU of 8hsv by Molmil
The structure of rat beta-arrestin1 in complex with a rat Mdm2 peptide
分子名称: Beta-arrestin-1, SULFATE ION, peptide from E3 ubiquitin-protein ligase Mdm2
著者Yun, Y, Yoon, H.J, Choi, Y, Lee, H.H.
登録日2022-12-20
公開日2023-07-19
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献GPCR targeting of E3 ubiquitin ligase MDM2 by inactive beta-arrestin.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F7A
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BU of 8f7a by Molmil
Cryo-EM structure of Importin-9 bound to RanGTP
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ...
著者Bernardes, N.E, Chook, Y.M.
登録日2022-11-18
公開日2023-07-26
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
7CYL
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BU of 7cyl by Molmil
Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
分子名称: RNA-binding protein FUS, Transportin-1
著者Yoshizawa, T, Chook, Y.M.
登録日2020-09-03
公開日2021-02-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Sci Rep, 11, 2021
7UNK
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BU of 7unk by Molmil
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
分子名称: Histone H3, Histone H4, Histone chaperone, ...
著者Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y.
登録日2022-04-11
公開日2022-09-21
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
2IU3
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BU of 2iu3 by Molmil
Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
分子名称: 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE, BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION
著者Xu, L, Chong, Y, Hwang, I, D'Onofrio, A, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A.
登録日2006-05-27
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
J. Biol. Chem., 282, 2007
2IU0
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BU of 2iu0 by Molmil
crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
分子名称: 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE, BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION
著者Xu, L, Chong, Y, Hwang, I, Onofrio, A.D, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A.
登録日2006-05-26
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structure-Based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase
J.Biol.Chem., 282, 2007
2OT8
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Karyopherin Beta2/Transportin-hnRNPM NLS Complex
分子名称: Heterogeneous nuclear ribonucleoprotein M, Transportin-1
著者Cansizoglu, A.E, Chook, Y.M.
登録日2007-02-07
公開日2007-04-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-based design of a pathway-specific nuclear import inhibitor.
Nat.Struct.Mol.Biol., 14, 2007

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