6XJS

Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)

Summary for 6XJS

• Entry DOI: 10.2210/pdb6xjs/pdb
• Descriptor: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (8 entities in total)
• Functional Keywords: nuclear export, crm1, xpo1, exportin-1, protein transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 159395.68

Authors

Baumhardt, J.M.,Chook, Y.M. (deposition date: 2020-06-24, release date: 2021-01-27, Last modification date: 2023-10-18)

• Primary citation: Walker, J.S.,Hing, Z.A.,Harrington, B.,Baumhardt, J.,Ozer, H.G.,Lehman, A.,Giacopelli, B.,Beaver, L.,Williams, K.,Skinner, J.N.,Cempre, C.B.,Sun, Q.,Shacham, S.,Stromberg, B.R.,Summers, M.K.,Abruzzo, L.V.,Rassenti, L.,Kipps, T.J.,Parikh, S.,Kay, N.E.,Rogers, K.A.,Woyach, J.A.,Coppola, V.,Chook, Y.M.,Oakes, C.,Byrd, J.C.,Lapalombella, R.; Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.; J Hematol Oncol, 14:17-17, 2021; PubMed: 33451349; DOI: 10.1186/s13045-021-01032-2

Experimental method

X-RAY DIFFRACTION (1.942 Å)