1K44
 
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7WVD
 | | Crystal structure of H14 complexed with SIA28 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SIA28, ... | | 著者 | Chen, Y, Qi, J, Gao, G.F. | | 登録日 | 2022-02-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | | 主引用文献 | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.
Nat Commun, 13, 2022
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7WVI
 | | Crystal structure of SIA28 | | 分子名称: | Heavy chain of SIA28, Light chain of SIA28 | | 著者 | Chen, Y, Qi, J, Gao, G.F. | | 登録日 | 2022-02-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.
Nat Commun, 13, 2022
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7WVG
 | | Crystal structure of H18 complexed with SIA28 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SIA28, ... | | 著者 | Chen, Y, Qi, J, Gao, G.F. | | 登録日 | 2022-02-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.
Nat Commun, 13, 2022
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7VRB
 | | Structure of the Human BRG1/SS18 complex | | 分子名称: | SMARCA4 protein,Protein SSXT | | 著者 | Cheng, Y, Chen, F, Zhou, H, Long, J. | | 登録日 | 2021-10-22 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.389 Å) | | 主引用文献 | Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
Nat Commun, 13, 2022
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6AWJ
 | | Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-MeO-N5Pan with pantothenate present in reaction | | 分子名称: | (2R)-2-hydroxy-N-{3-[(5-methoxypentyl)amino]-3-oxopropyl}-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, Type II pantothenate kinase | | 著者 | Chen, Y, Antoshchenko, T, Strauss, E, Barnard, L, Huang, Y.H. | | 登録日 | 2017-09-05 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
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6AWI
 | | Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-N5Pan | | 分子名称: | (2R)-2-hydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide, ADENOSINE-5'-DIPHOSPHATE, Type II pantothenate kinase | | 著者 | Chen, Y, Antoshchenko, T, Strauss, E, Barnard, L, Huang, Y.H. | | 登録日 | 2017-09-05 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
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7WVB
 | | Human Fructose-1,6-bisphosphatase 1 mutant R50A in APO R-state | | 分子名称: | Fructose-1,6-bisphosphatase 1 | | 著者 | Chen, Y, Zhang, J, Li, C, Cao, Y. | | 登録日 | 2022-02-10 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Human Fructose-1,6-bisphosphatase 1 mutant R50A in APO R-state
To Be Published
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6XF4
 | | Crystal structure of STING REF variant in complex with E7766 | | 分子名称: | (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name), 1,2-ETHANEDIOL, Stimulator of interferon genes protein | | 著者 | Chen, Y, Wang, J.Y, Kim, D.-S. | | 登録日 | 2020-06-15 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
Chemmedchem, 16, 2021
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6XF3
 | | Crystal structure of STING in complex with E7766 | | 分子名称: | (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name), Stimulator of interferon genes protein | | 著者 | Chen, Y, Wang, J.Y, Kim, D.-S. | | 登録日 | 2020-06-15 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
Chemmedchem, 16, 2021
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7VRC
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8CTM
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4CS6
 | | Crystal structure of AadA - an aminoglycoside adenyltransferase | | 分子名称: | AMINOGLYCOSIDE ADENYLTRANSFERASE | | 著者 | Chen, Y, Nasvall, J, Andersson, D.I, Selmer, M. | | 登録日 | 2014-03-05 | | 公開日 | 2015-03-25 | | 最終更新日 | 2015-11-11 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | Structure of Aada from Salmonella Enterica: A Monomeric Aminoglycoside (3'')(9) Adenyltransferase.
Acta Crystallogr.,Sect.D, 71, 2015
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7OKX
 | | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite structure) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | | 登録日 | 2021-05-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Mol.Cell, 81, 2021
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7OL0
 | | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | | 登録日 | 2021-05-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Mol.Cell, 81, 2021
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7OKY
 | | Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | | 登録日 | 2021-05-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Mol.Cell, 81, 2021
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6KOR
 | | Crystal structure of the RRM domain of SYNCRIP | | 分子名称: | Heterogeneous nuclear ribonucleoprotein Q | | 著者 | Chen, Y, Chan, J, Chen, W, Jobichen, C. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | SYNCRIP, a new player in pri-let-7a processing.
Rna, 26, 2020
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9C1F
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9C1E
 | | Mink RyR3 in closed conformation | | 分子名称: | CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 3, ... | | 著者 | Chen, Y.S, Van Petegem, F. | | 登録日 | 2024-05-29 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Cryo-EM investigation of ryanodine receptor type 3.
Nat Commun, 15, 2024
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8T7C
 | | Crystal structure of human phospholipase C gamma 2 | | 分子名称: | 1,2-ETHANEDIOL, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, CALCIUM ION | | 著者 | Chen, Y, Choi, H, Zhuang, N, Hu, L, Qian, D, Wang, J. | | 登録日 | 2023-06-20 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition
To Be Published
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1MIC
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6UED
 | | Apo Pseudomonas aeruginosa LpxD Structure | | 分子名称: | GLYCEROL, MAGNESIUM ION, UDP-3-O-acylglucosamine N-acyltransferase | | 著者 | Chen, Y, Kroeck, K, Sacco, M. | | 登録日 | 2019-09-20 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Sci Rep, 9, 2019
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6LQX
 | | Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7 | | 分子名称: | (1~{S},6~{R})-6-[(1-methoxycarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid, CREB-binding protein, SODIUM ION | | 著者 | Chen, Y, Zhang, F, Sun, Z, Bi, X, Luo, C. | | 登録日 | 2020-01-14 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Design, synthesis and biological evaluation of novel small molecule inhibitor of the CBP bromodomain with possible anti-leukemia effects
To Be Published
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3P2T
 | | Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k) | | 分子名称: | Leukocyte immunoglobulin-like receptor subfamily B member 4, SULFATE ION | | 著者 | Chen, Y, Nam, G, Cheng, H, Zhang, J.H, Willcox, B.E, Gao, G.F. | | 登録日 | 2010-10-04 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance
J.Biol.Chem., 286, 2011
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1FLO
 | | FLP Recombinase-Holliday Junction Complex I | | 分子名称: | FLP RECOMBINASE, PHOSPHONIC ACID, SYMMETRIZED FRT DNA SITES | | 著者 | Chen, Y, Narendra, U, Iype, L.E, Cox, M.M, Rice, P.A. | | 登録日 | 2000-08-14 | | 公開日 | 2000-09-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping.
Mol.Cell, 6, 2000
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