6LQX

Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7

Summary for 6LQX

• Entry DOI: 10.2210/pdb6lqx/pdb
• Descriptor: CREB-binding protein, (1~{S},6~{R})-6-[(1-methoxycarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid, SODIUM ION, ... (4 entities in total)
• Functional Keywords: inhibitor, cbp, p300, bromodomain, lc-cpin7, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 55659.65

Authors

Chen, Y.,Zhang, F.,Sun, Z.,Bi, X.,Luo, C. (deposition date: 2020-01-14, release date: 2021-01-20, Last modification date: 2023-11-29)

• Primary citation: Chen, Y.,Bi, X.,Zhang, F.,Sun, Z.,Luo, C.; Design, synthesis and biological evaluation of novel small molecule inhibitor of the CBP bromodomain with possible anti-leukemia effects; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.46 Å)