6LQX
Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7
Summary for 6LQX
Entry DOI | 10.2210/pdb6lqx/pdb |
Descriptor | CREB-binding protein, (1~{S},6~{R})-6-[(1-methoxycarbonyl-3,4-dihydro-2~{H}-quinolin-6-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid, SODIUM ION, ... (4 entities in total) |
Functional Keywords | inhibitor, cbp, p300, bromodomain, lc-cpin7, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 55659.65 |
Authors | |
Primary citation | Chen, Y.,Bi, X.,Zhang, F.,Sun, Z.,Luo, C. Design, synthesis and biological evaluation of novel small molecule inhibitor of the CBP bromodomain with possible anti-leukemia effects To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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