4XK0
| Crystal structure of a tetramolecular RNA G-quadruplex in potassium | Descriptor: | BARIUM ION, POTASSIUM ION, RNA (5'-(*UP*GP*GP*GP*GP*U)-3') | Authors: | Chen, M.C, Murat, P, Abecassis, K.A, Ferre-D'Amare, A.R, Balasubramanian, S. | Deposit date: | 2015-01-09 | Release date: | 2015-02-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase. Nucleic Acids Res., 43, 2015
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8U28
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8U2C
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8U26
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6TCL
| Photosystem I tetramer | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Chen, M, Perez-Boerema, A, Li, S, Amunts, A. | Deposit date: | 2019-11-06 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Distinct structural modulation of photosystem I and lipid environment stabilizes its tetrameric assembly. Nat.Plants, 6, 2020
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7PTY
| Delta-latroinsectotoxin dimer | Descriptor: | Delta-latroinsectotoxin-Lt1a | Authors: | Chen, M, Gatsogiannis, C. | Deposit date: | 2021-09-27 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (4.63 Å) | Cite: | Molecular architecture of black widow spider neurotoxins. Nat Commun, 12, 2021
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7PTX
| Alpha-latrocrustotoxin monomer | Descriptor: | Alpha-latrocrustotoxin-Lt1a | Authors: | Chen, M, Gatsogiannis, C. | Deposit date: | 2021-09-27 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Molecular architecture of black widow spider neurotoxins. Nat Commun, 12, 2021
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5IVG
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8JTN
| Tudor domain of TDRD3 in complex with a small molecule | Descriptor: | 2-propyl-2-azoniatricyclo[7.3.0.0^{3,7}]dodeca-1(9),2,7-trien-8-amine, Tudor domain-containing protein 3 | Authors: | Chen, M, Wang, Z, Li, W, Shang, X, Liu, Y. | Deposit date: | 2023-06-22 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist. Biochim Biophys Acta Gene Regul Mech, 1866, 2023
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5VHD
| DHX36 with an N-terminal truncation bound to ADP-AlF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DEAH (Asp-Glu-Ala-His) box polypeptide 36, TETRAFLUOROALUMINATE ION | Authors: | Chen, M, Ferre-D'Amare, A. | Deposit date: | 2017-04-13 | Release date: | 2018-06-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature, 558, 2018
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5VHC
| DHX36 with an N-terminal truncation bound to ADP-BeF3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DEAH (Asp-Glu-Ala-His) box polypeptide 36, ... | Authors: | Chen, M, Ferre-D'Amare, A. | Deposit date: | 2017-04-12 | Release date: | 2018-06-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature, 558, 2018
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5VHE
| DHX36 in complex with the c-Myc G-quadruplex | Descriptor: | DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION | Authors: | Chen, M, Ferre-D'Amare, A. | Deposit date: | 2017-04-13 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.793 Å) | Cite: | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature, 558, 2018
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8K3S
| Structure of PKD2-F604P complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | Deposit date: | 2023-07-16 | Release date: | 2024-04-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands. Proc.Natl.Acad.Sci.USA, 121, 2024
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1Y2A
| Structure of mammalian importin bound to the non-classical PLSCR1-NLS | Descriptor: | Importin alpha-2 Subunit, decamer fragment of Phospholipid scramblase 1 | Authors: | Chen, M.-H, Ben-Efraim, I, Mitrousis, G, Walker-Kopp, N, Sims, P.J, Cingolani, G. | Deposit date: | 2004-11-22 | Release date: | 2005-02-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Phospholipid Scramblase 1 Contains a Nonclassical Nuclear Localization Signal with Unique Binding Site in Importin alpha J.Biol.Chem., 280, 2005
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8HK7
| Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, CALCIUM ION, ... | Authors: | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | Deposit date: | 2022-11-25 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands. Proc.Natl.Acad.Sci.USA, 121, 2024
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4DBS
| Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid | Descriptor: | 3-[(4-nitronaphthalen-1-yl)amino]benzoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Chen, M, Christianson, D.W, Winkler, J.D, Penning, T.M. | Deposit date: | 2012-01-16 | Release date: | 2012-03-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.852 Å) | Cite: | Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorg.Med.Chem.Lett., 22, 2012
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5B4E
| Sulfur Transferase TtuA in complex with iron sulfur cluster and ATP derivative | Descriptor: | IRON/SULFUR CLUSTER, ISOPROPYL ALCOHOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Chen, M, Narai, S, Tanaka, Y, Yao, M. | Deposit date: | 2016-04-03 | Release date: | 2017-05-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4DBU
| Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid | Descriptor: | 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Chen, M, Christianson, D.W, Winkler, J.D, Penning, T.M. | Deposit date: | 2012-01-16 | Release date: | 2012-03-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.528 Å) | Cite: | Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorg.Med.Chem.Lett., 22, 2012
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4DBW
| Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 2'-desmethyl-indomethacin | Descriptor: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl]acetic acid | Authors: | Chen, M, Christianson, D.W, Marnett, L.J, Penning, T.M. | Deposit date: | 2012-01-16 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17 beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J.Med.Chem., 56, 2013
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5B4F
| Sulfur Transferase TtuA in complex with iron sulfur cluster | Descriptor: | IRON/SULFUR CLUSTER, SULFATE ION, Sulfur Transferase TtuA, ... | Authors: | Chen, M, Narai, S, Tanaka, Y, Yao, M. | Deposit date: | 2016-04-03 | Release date: | 2017-05-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3SY8
| Crystal structure of the response regulator RocR | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, RocR | Authors: | Chen, M.W, Kotaka, M, Vonrhein, C, Bricogne, G, Lescar, J. | Deposit date: | 2011-07-16 | Release date: | 2012-07-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling. J.Bacteriol., 194, 2012
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8HWN
| aldo-keto reductase DepB | Descriptor: | CHLORIDE ION, DepB, SODIUM ION | Authors: | Chen, M, Yang, H, Lu, F. | Deposit date: | 2022-12-31 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of DepB capable of DON detoxification To Be Published
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3W9Z
| Crystal structure of DusC | Descriptor: | FLAVIN MONONUCLEOTIDE, tRNA-dihydrouridine synthase C | Authors: | Chen, M, Yu, J, Tanaka, Y, Tanaka, I, Yao, M. | Deposit date: | 2013-04-19 | Release date: | 2013-07-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of dihydrouridine synthase C (DusC) from Escherichia coli Acta Crystallogr.,Sect.F, 69, 2013
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3UZX
| Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and epiandrosterone | Descriptor: | (3Beta,5alpha)-3-Hydroxyandrostan-17-one, 3-oxo-5-beta-steroid 4-dehydrogenase, 5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL, ... | Authors: | Chen, M, Christianson, D.W, Penning, T.M. | Deposit date: | 2011-12-07 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.637 Å) | Cite: | Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING. J.Biol.Chem., 287, 2012
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3UZZ
| Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and delta4-androstenedione | Descriptor: | 3-oxo-5-beta-steroid 4-dehydrogenase, 4-ANDROSTENE-3-17-DIONE, CHLORIDE ION, ... | Authors: | Chen, M, Christianson, D.W, Penning, T.M. | Deposit date: | 2011-12-07 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING. J.Biol.Chem., 287, 2012
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