8HK7

Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1

Summary for 8HK7

• Entry DOI: 10.2210/pdb8hk7/pdb
• EMDB information: 34848
• Descriptor: Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 268263.57

Authors

Chen, M.Y.,Su, Q.,Wang, Z.F.,Yu, Y. (deposition date: 2022-11-25, release date: 2024-03-27)

• Primary citation: Wang, Z.,Chen, M.,Su, Q.,Morais, T.D.C.,Wang, Y.,Nazginov, E.,Pillai, A.R.,Qian, F.,Shi, Y.,Yu, Y.; Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.; Proc.Natl.Acad.Sci.USA, 121:e2316230121-e2316230121, 2024; PubMed: 38483987; DOI: 10.1073/pnas.2316230121

Experimental method

ELECTRON MICROSCOPY (3 Å)