8HK7
Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Polycystin-2 | polymer | 571 | 66029.8 | 4 | UniProt (Q13563) Pfam (PF20519) Pfam (PF00520) Pfam (PF08016) In PDB | Homo sapiens (human) | PC2,Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2 |
| 2 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 3 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | A, B, C, D | 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione | non-polymer | 362.4 | 4 | Chemie (AQV) |
Sequence modifications
A, B, C, D: 185 - 719 (UniProt: Q13563)
| PDB | External Database | Details |
|---|---|---|
| Met 149 | - | initiating methionine |
| Ser 150 | - | expression tag |
| Ala 151 | - | expression tag |
| Trp 152 | - | expression tag |
| Ser 153 | - | expression tag |
| His 154 | - | expression tag |
| Pro 155 | - | expression tag |
| Gln 156 | - | expression tag |
| Phe 157 | - | expression tag |
| Glu 158 | - | expression tag |
| Lys 159 | - | expression tag |
| Gly 160 | - | expression tag |
| Gly 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Ser 163 | - | expression tag |
| Gly 164 | - | expression tag |
| Gly 165 | - | expression tag |
| Gly 166 | - | expression tag |
| Ser 167 | - | expression tag |
| Gly 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Ser 170 | - | expression tag |
| Ala 171 | - | expression tag |
| Trp 172 | - | expression tag |
| Ser 173 | - | expression tag |
| His 174 | - | expression tag |
| Pro 175 | - | expression tag |
| Gln 176 | - | expression tag |
| Phe 177 | - | expression tag |
| Glu 178 | - | expression tag |
| Lys 179 | - | expression tag |
| Gly 180 | - | expression tag |
| Ser 181 | - | expression tag |
| Ala 182 | - | expression tag |
| Ala 183 | - | expression tag |
| Ala 184 | - | expression tag |
| Pro 604 | Phe 604 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 264119.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4144.3 | |
| All* | Total formula weight | 268263.6 |
