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PDB: 616 件
5YWC
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BU of 5ywc by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW9
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Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWB
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BU of 5ywb by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-30
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW8
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BU of 5yw8 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWA
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BU of 5ywa by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
7Y4S
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BU of 7y4s by Molmil
Structure of human MG53 homo-dimer
分子名称: Tripartite motif-containing protein 72
著者Chen, L, Niu, Y.
登録日2022-06-16
公開日2022-09-21
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of human MG53 homodimer.
Biochem.J., 479, 2022
6JT0
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BU of 6jt0 by Molmil
Structure of human soluble guanylate cyclase in the unliganded state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-08-28
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6JT1
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Structure of human soluble guanylate cyclase in the heme oxidised state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-08-28
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6L65
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BU of 6l65 by Molmil
Sirtuin 2 protein with H3K18 myristoylated peptide
分子名称: MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ...
著者Chen, L.F.
登録日2019-10-28
公開日2020-11-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L66
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BU of 6l66 by Molmil
Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule
分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
著者Chen, L.F.
登録日2019-10-28
公開日2020-11-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.169 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
7W4O
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BU of 7w4o by Molmil
The structure of KATP H175K mutant in pre-open state
分子名称: 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Chen, L, Wang, M.
登録日2021-11-28
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
7W4P
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BU of 7w4p by Molmil
The structure of KATP H175K mutant in closed state
分子名称: 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Chen, L, Wang, M.
登録日2021-11-28
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
6L72
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BU of 6l72 by Molmil
Sirtuin 2 demyristoylation native final product
分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate
著者Chen, L.F.
登録日2019-10-30
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L71
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BU of 6l71 by Molmil
Sirtuin 2 demyristoylation native intermediate I & II mixture
分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
著者Chen, L.F.
登録日2019-10-30
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.109 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
7WDB
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BU of 7wdb by Molmil
Human TRPC5 channel in complex with riluzole
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ...
著者Chen, L, Wei, M, Yang, Y.
登録日2021-12-21
公開日2022-04-13
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structural identification of riluzole-binding site on human TRPC5.
Cell Discov, 8, 2022
7WWG
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BU of 7wwg by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation
分子名称: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1
著者Chen, L, Tan, L, Im, Y.J.
登録日2022-02-12
公開日2022-07-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7WWE
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BU of 7wwe by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 in an apo form
分子名称: Phosphatidylinositol transfer protein CSR1
著者Chen, L, Tan, L, Im, Y.J.
登録日2022-02-12
公開日2022-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7WWD
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BU of 7wwd by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with squalene
分子名称: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, Phosphatidylinositol transfer protein CSR1
著者Chen, L, Tan, L, Im, Y.J.
登録日2022-02-12
公開日2022-07-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7WVT
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BU of 7wvt by Molmil
Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol
分子名称: (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1
著者Chen, L, Tan, L, Im, Y.J.
登録日2022-02-11
公開日2022-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
7D9R
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BU of 7d9r by Molmil
Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9U
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BU of 7d9u by Molmil
Structure of human soluble guanylate cyclase in the cinciguat-bound activated state
分子名称: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ...
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9S
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BU of 7d9s by Molmil
Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9T
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BU of 7d9t by Molmil
Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state
分子名称: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
5Z1F
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BU of 5z1f by Molmil
Structure of atOSCA3.1 channel
分子名称: CSC1-like protein ERD4
著者Chen, L, Zhang, M, Kang, Y, Wu, J.X.
登録日2017-12-26
公開日2018-09-12
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structure of the mechanosensitive OSCA channels.
Nat. Struct. Mol. Biol., 25, 2018
5YWD
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BU of 5ywd by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, MAGNESIUM ION
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018

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