7Y4S

Structure of human MG53 homo-dimer

Summary for 7Y4S

• Entry DOI: 10.2210/pdb7y4s/pdb
• EMDB information: 33606
• Descriptor: Tripartite motif-containing protein 72 (1 entity in total)
• Functional Keywords: tripartite motif-containing protein 72, mg53, trim72, membrane repair, pry-spry domain, mitsugumin-53, structural protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 105601.02

Authors

Chen, L.,Niu, Y. (deposition date: 2022-06-16, release date: 2022-09-21, Last modification date: 2024-07-03)

Primary citation

Niu, Y.,Chen, G.,Lv, F.,Xiao, R.P.,Hu, X.,Chen, L.
Cryo-EM structure of human MG53 homodimer.
Biochem.J., 479:1909-1916, 2022

PubMed Abstract: MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a 'body' and two 'wings'. Intermolecular interactions are mainly distributed in the 'body' which is relatively stable, while two 'wings' are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family.

PubMed: 36053137
DOI: 10.1042/BCJ20220385

Experimental method

ELECTRON MICROSCOPY (3.5 Å)