6OR6
| Full-length S. pombe Mdn1 in the presence of AMPPNP (tail region) | Descriptor: | Midasin | Authors: | Chen, Z, Suzuki, H, Wang, A.C, DiMaio, F, Walz, T, Kapoor, T.M. | Deposit date: | 2019-04-29 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.3 Å) | Cite: | Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis. Cell, 175, 2018
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6L5M
| Crystal structure of human DEAD-box RNA helicase DDX21 in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Nucleolar RNA helicase 2 | Authors: | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | Deposit date: | 2019-10-24 | Release date: | 2020-06-17 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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6L5L
| Crystal structure of human DEAD-box RNA helicase DDX21 at apo state | Descriptor: | MAGNESIUM ION, Nucleolar RNA helicase 2 | Authors: | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | Deposit date: | 2019-10-24 | Release date: | 2020-06-17 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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6L5N
| Crystal structure of human DEAD-box RNA helicase DDX21 at post-unwound state | Descriptor: | MAGNESIUM ION, Nucleolar RNA helicase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | Deposit date: | 2019-10-24 | Release date: | 2020-06-17 | Last modified: | 2020-08-12 | Method: | X-RAY DIFFRACTION (2.242 Å) | Cite: | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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5WUK
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6L30
| Crystal structure of the epithelial cell transforming 2 (ECT2) | Descriptor: | Protein ECT2 | Authors: | Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. | Deposit date: | 2019-10-07 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
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1A6T
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3KZ1
| Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ... | Authors: | Chen, Z, Sternweis, P.C, Sprang, S.R. | Deposit date: | 2009-12-07 | Release date: | 2010-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285, 2010
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6V09
| Crystal structure of human recombinant Beta-2 glycoprotein I short tag (ST-B2GPI) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-glycoprotein 1, SULFATE ION, ... | Authors: | Chen, Z, Ruben, E.A, Planer, W, Chinnaraj, M, Zuo, X, Pengo, V, Macor, P, Tedesco, F, Pozzi, N. | Deposit date: | 2019-11-18 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. J.Biol.Chem., 295, 2020
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6V06
| Crystal structure of Beta-2 glycoprotein I purified from plasma (pB2GPI) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-glycoprotein 1, ... | Authors: | Chen, Z, Ruben, E.A, Planer, W, Chinnaraj, M, Zuo, X, Pengo, V, Macor, P, Tedesco, F, Pozzi, N. | Deposit date: | 2019-11-18 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. J.Biol.Chem., 295, 2020
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7VX8
| Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1 | Authors: | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2021-11-12 | Release date: | 2022-05-18 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
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7VWC
| Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1 | Descriptor: | Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, [(2R)-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-oxidanyl-propyl] octadecanoate | Authors: | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2021-11-10 | Release date: | 2022-05-18 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
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7VZB
| Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1 | Descriptor: | CHOLESTEROL HEMISUCCINATE, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate | Authors: | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2021-11-15 | Release date: | 2022-05-18 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
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7VOE
| Crystal structure of 5-HT2AR in complex with aripiprazole | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, ... | Authors: | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | Deposit date: | 2021-10-13 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25, 2022
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7VOD
| Crystal structure of 5-HT2AR in complex with cariprazine | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | Authors: | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | Deposit date: | 2021-10-13 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25, 2022
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1BMV
| PROTEIN-RNA INTERACTIONS IN AN ICOSAHEDRAL VIRUS AT 3.0 ANGSTROMS RESOLUTION | Descriptor: | PROTEIN (ICOSAHEDRAL VIRUS - A DOMAIN), PROTEIN (ICOSAHEDRAL VIRUS - B AND C DOMAIN), RNA (5'-R(*GP*GP*UP*CP*AP*AP*AP*AP*UP*GP*C)-3') | Authors: | Chen, Z, Stauffacher, C, Li, Y, Schmidt, T, Bomu, W, Kamer, G, Shanks, M, Lomonossoff, G, Johnson, J.E. | Deposit date: | 1989-10-09 | Release date: | 1989-10-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Protein-RNA interactions in an icosahedral virus at 3.0 A resolution. Science, 245, 1989
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8EOI
| Structure of a human EMC:human Cav1.2 channel complex in GDN detergent | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L. | Deposit date: | 2022-10-03 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | EMC chaperone-Ca V structure reveals an ion channel assembly intermediate. Nature, 619, 2023
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8EOG
| Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine | Descriptor: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L. | Deposit date: | 2022-10-03 | Release date: | 2023-05-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | EMC chaperone-Ca V structure reveals an ion channel assembly intermediate. Nature, 619, 2023
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8FD7
| Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin | Descriptor: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, Z, Mondal, A, Minor, D.L. | Deposit date: | 2022-12-02 | Release date: | 2023-03-22 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for Ca V alpha 2 delta :gabapentin binding. Nat.Struct.Mol.Biol., 30, 2023
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5VF3
| Bacteriophage T4 isometric capsid | Descriptor: | Capsid vertex protein gp24, Highly immunogenic outer capsid protein, Major capsid protein, ... | Authors: | Chen, Z, Sun, L, Zhang, Z, Fokine, A, Padilla-Sanchez, V, Hanein, D, Jiang, W, Rossmann, M.G, Rao, V.B. | Deposit date: | 2017-04-06 | Release date: | 2017-09-13 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of the bacteriophage T4 isometric head at 3.3- angstrom resolution and its relevance to the assembly of icosahedral viruses. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8D6T
| Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) | Descriptor: | CACODYLATE ION, Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | Deposit date: | 2022-06-06 | Release date: | 2022-11-02 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family. Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6P
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8D6Q
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8D6S
| Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) | Descriptor: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | Deposit date: | 2022-06-06 | Release date: | 2022-11-02 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family. Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6U
| Rana catesbeiana saxiphilin:F-STX (soaked) | Descriptor: | (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid, Saxiphilin | Authors: | Chen, Z, Zakrzewska, S, Minor, D.L. | Deposit date: | 2022-06-06 | Release date: | 2022-11-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family. Proc.Natl.Acad.Sci.USA, 119, 2022
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