7VOE

Crystal structure of 5-HT2AR in complex with aripiprazole

Summary for 7VOE

• Entry DOI: 10.2210/pdb7voe/pdb
• Related: 7VOD
• Descriptor: 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, PENTAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: gpcr, dopamine receptor, serotonin receptor, aripiprazole, antipsychotic, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 45255.16

Authors

Chen, Z.,Fan, L.,Wang, H.,Yu, J.,Lu, D.,Qi, J.,Nie, F.,Luo, Z.,Liu, Z.,Cheng, J.,Wang, S. (deposition date: 2021-10-13, release date: 2021-12-22, Last modification date: 2023-11-29)

• Primary citation: Chen, Z.,Fan, L.,Wang, H.,Yu, J.,Lu, D.,Qi, J.,Nie, F.,Luo, Z.,Liu, Z.,Cheng, J.,Wang, S.; Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.; Nat.Neurosci., 25:39-49, 2022; PubMed: 34887590; DOI: 10.1038/s41593-021-00971-w

Experimental method

X-RAY DIFFRACTION (2.9 Å)