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PDB: 20 件
8TUA
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BU of 8tua by Molmil
Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2023-08-15
公開日2024-04-10
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
Elife, 2024
6PCV
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Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1
著者Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G.
登録日2019-06-18
公開日2019-10-23
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
6BNM
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BU of 6bnm by Molmil
Crystal Structure of the P-Rex2 PH domain
分子名称: CHLORIDE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
著者Cash, J.N, Sharma, P.V, Tesmer, J.J.G.
登録日2017-11-17
公開日2018-11-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3.
J.Struct.Biol., 1, 2019
3SEK
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BU of 3sek by Molmil
Crystal Structure of the Myostatin:Follistatin-like 3 Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8
著者Cash, J.N, Thompson, T.B.
登録日2011-06-10
公開日2011-11-02
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.
J.Biol.Chem., 287, 2012
5FI0
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BU of 5fi0 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1
分子名称: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-12-22
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.282 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5FI1
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BU of 5fi1 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-12-22
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.203 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
3HH2
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Crystal structure of the myostatin:follistatin 288 complex
分子名称: CITRIC ACID, Follistatin, Growth/differentiation factor 8, ...
著者Cash, J.N, Thompson, T.B.
登録日2009-05-14
公開日2009-08-04
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding
Embo J., 28, 2009
5D3V
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Crystal Structure of the P-Rex1 PH domain with Citrate Bound
分子名称: CITRATE ANION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3W
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Crystal Structure of the P-Rex1 PH domain with Sulfate Bound
分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, SULFATE ION
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3X
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Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D27
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Crystal Structure of the P-Rex1 PH domain
分子名称: NICKEL (II) ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-05
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3Y
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BU of 5d3y by Molmil
Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-08-06
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
7SJ4
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BU of 7sj4 by Molmil
Human Trio residues 1284-1959 in complex with Rac1
分子名称: Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein
著者Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G.
登録日2021-10-15
公開日2022-07-06
最終更新日2022-08-24
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
J.Biol.Chem., 298, 2022
6WJG
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BU of 6wjg by Molmil
PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma
分子名称: DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit
著者Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S.
登録日2020-04-13
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Plos Biol., 18, 2020
6WJF
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BU of 6wjf by Molmil
PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma
分子名称: DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit
著者Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S.
登録日2020-04-13
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Plos Biol., 18, 2020
7K9X
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BU of 7k9x by Molmil
Aldolase, rabbit muscle (beam-tilt refinement x1)
分子名称: Fructose-bisphosphate aldolase A
著者Kearns, S.K, Cash, J.N, Cianfrocco, M.A.
登録日2020-09-29
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献High-resolution cryo-EM using beam-image shift at 200 keV.
Iucrj, 7, 2020
7K9L
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BU of 7k9l by Molmil
Aldolase, rabbit muscle (no beam-tilt refinement)
分子名称: Fructose-bisphosphate aldolase A
著者Cianfrocco, M.A, Kearns, S.E, Cash, J.N, Li, Y.
登録日2020-09-29
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献High-resolution cryo-EM using beam-image shift at 200 keV.
Iucrj, 7, 2020
7KA2
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BU of 7ka2 by Molmil
Aldolase, rabbit muscle (beam-tilt refinement x2)
分子名称: Fructose-bisphosphate aldolase A
著者Kearns, S.K, Cash, J.N, Cianfrocco, M.A, Li, Y.
登録日2020-09-29
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献High-resolution cryo-EM using beam-image shift at 200 keV.
Iucrj, 7, 2020
7KA4
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BU of 7ka4 by Molmil
Aldolase, rabbit muscle (beam-tilt refinement x4)
分子名称: Fructose-bisphosphate aldolase A
著者Kearns, S.K, Cash, J.N, Cianfrocco, M.A, Li, Y.
登録日2020-09-29
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献High-resolution cryo-EM using beam-image shift at 200 keV.
Iucrj, 7, 2020
7KA3
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Aldolase, rabbit muscle (beam-tilt refinement x3)
分子名称: Fructose-bisphosphate aldolase A
著者Kearns, S.K, Cash, J.N, Cianfrocco, M.A, Li, Y.
登録日2020-09-29
公開日2020-12-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献High-resolution cryo-EM using beam-image shift at 200 keV.
Iucrj, 7, 2020

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件を2024-05-15に公開中

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