3V6L
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![BU of 3v6l by Molmil](/molmil-images/mine/3v6l) | Crystal Structure of caspase-6 inactivation mutation | Descriptor: | Caspase-6 | Authors: | Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. | Deposit date: | 2011-12-20 | Release date: | 2012-03-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287, 2012
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3V6M
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![BU of 3v6m by Molmil](/molmil-images/mine/3v6m) | Inhibition of caspase-6 activity by single mutation outside the active site | Descriptor: | Caspase-6 | Authors: | Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. | Deposit date: | 2011-12-20 | Release date: | 2012-03-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.692 Å) | Cite: | Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287, 2012
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6VW2
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![BU of 6vw2 by Molmil](/molmil-images/mine/6vw2) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils | Descriptor: | Islet amyloid polypeptide (SUMO-tagged) | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2020-02-18 | Release date: | 2020-06-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat.Struct.Mol.Biol., 27, 2020
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7M61
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![BU of 7m61 by Molmil](/molmil-images/mine/7m61) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M64
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![BU of 7m64 by Molmil](/molmil-images/mine/7m64) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M62
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![BU of 7m62 by Molmil](/molmil-images/mine/7m62) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M65
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![BU of 7m65 by Molmil](/molmil-images/mine/7m65) | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7SAS
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![BU of 7sas by Molmil](/molmil-images/mine/7sas) | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAQ
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![BU of 7saq by Molmil](/molmil-images/mine/7saq) | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAR
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![BU of 7sar by Molmil](/molmil-images/mine/7sar) | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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4IYR
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![BU of 4iyr by Molmil](/molmil-images/mine/4iyr) | Crystal structure of full-length caspase-6 zymogen | Descriptor: | Caspase-6 | Authors: | Cao, Q, Wang, X.-J, Li, L.-F, Su, X.-D. | Deposit date: | 2013-01-29 | Release date: | 2014-01-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays. Acta Crystallogr.,Sect.D, 70, 2014
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6N3A
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![BU of 6n3a by Molmil](/molmil-images/mine/6n3a) | SegA-long, conformation of TDP-43 low complexity domain segment A long | Descriptor: | TAR DNA-binding protein 43, segA long small | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6N3C
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![BU of 6n3c by Molmil](/molmil-images/mine/6n3c) | SegB, conformation of TDP-43 low complexity domain segment A | Descriptor: | TAR DNA-binding protein 43 | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6N3B
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![BU of 6n3b by Molmil](/molmil-images/mine/6n3b) | SegA-asym, conformation of TDP-43 low complexity domain segment A asym | Descriptor: | TAR DNA-binding protein 43 | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6N37
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![BU of 6n37 by Molmil](/molmil-images/mine/6n37) | SegA-sym, conformation of TDP-43 low complexity domain segment A sym | Descriptor: | TAR DNA-binding protein 43 | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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8JMV
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![BU of 8jmv by Molmil](/molmil-images/mine/8jmv) | |
8JMW
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![BU of 8jmw by Molmil](/molmil-images/mine/8jmw) | Fibril form of serine peptidase Vpr | Descriptor: | S8 family serine peptidase | Authors: | Cao, Q, Cheng, Y. | Deposit date: | 2023-06-05 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. Nat Commun, 14, 2023
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6BCS
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![BU of 6bcs by Molmil](/molmil-images/mine/6bcs) | LilrB2 D1D2 domains complexed with benzamidine | Descriptor: | BENZAMIDINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Cao, Q, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-10-20 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem, 10, 2018
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6WPQ
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![BU of 6wpq by Molmil](/molmil-images/mine/6wpq) | GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | Descriptor: | Heterogeneous nuclear ribonucleoprotein A2 | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-27 | Release date: | 2020-08-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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6WQK
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![BU of 6wqk by Molmil](/molmil-images/mine/6wqk) | hnRNPA2 Low complexity domain (LCD) determined by cryoEM | Descriptor: | MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-29 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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3L9T
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![BU of 3l9t by Molmil](/molmil-images/mine/3l9t) | |
3L87
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![BU of 3l87 by Molmil](/molmil-images/mine/3l87) | |
3OD5
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![BU of 3od5 by Molmil](/molmil-images/mine/3od5) | Crystal structure of active caspase-6 bound with Ac-VEID-CHO | Descriptor: | CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO | Authors: | Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. | Deposit date: | 2010-08-11 | Release date: | 2010-10-27 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
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6M5F
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![BU of 6m5f by Molmil](/molmil-images/mine/6m5f) | Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas aeruginosa | Descriptor: | Probable transcriptional regulator | Authors: | Wang, Y, Lan, L, Cao, Q, Gan, J, Wang, F. | Deposit date: | 2020-03-10 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas aeruginosa To Be Published
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6CB9
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![BU of 6cb9 by Molmil](/molmil-images/mine/6cb9) | Segment AALQSS from the low complexity domain of TDP-43, residues 328-333 | Descriptor: | AALQSS | Authors: | Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-02-02 | Release date: | 2018-04-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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