8AE5
 
 | | Crystal structure of human legumain in complex with macrocypin 1a | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Legumain, ... | | Authors: | Elamin, T, Brandstetter, H, Dall, E. | | Deposit date: | 2022-07-12 | | Release date: | 2022-09-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction.
J.Biol.Chem., 298, 2022
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4BQD
 | | KD1 of human TFPI in complex with a synthetic peptide | | Descriptor: | GLYCEROL, PEPTIDE, TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR) VARIANT | | Authors: | Griessner, A, Brandstetter, H. | | Deposit date: | 2013-05-30 | | Release date: | 2013-12-04 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi)
J.Biol.Chem., 289, 2014
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5JBB
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5JBC
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5JB8
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5JB9
 | | Crystal structure of factor IXa K98T variant in complex with PPACK | | Descriptor: | CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... | | Authors: | Kristensen, L.H, Brandstetter, H. | | Deposit date: | 2016-04-13 | | Release date: | 2016-06-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Biochem.J., 473, 2016
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5JBA
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2WPI
 | | factor IXa superactive double mutant | | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | | Authors: | Zogg, T, Brandstetter, H. | | Deposit date: | 2009-08-06 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
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2WPM
 | | factor IXa superactive mutant, EGR-CMK inhibited | | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | | Authors: | Zogg, T, Brandstetter, H. | | Deposit date: | 2009-08-06 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
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2WPH
 | | factor IXa superactive triple mutant | | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | | Authors: | Zogg, T, Brandstetter, H. | | Deposit date: | 2009-08-06 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
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2WPK
 | | factor IXa superactive triple mutant, ethylene glycol-soaked | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, ... | | Authors: | Zogg, T, Brandstetter, H. | | Deposit date: | 2009-08-06 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
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2WPL
 | | factor IXa superactive triple mutant, EDTA-soaked | | Descriptor: | COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, D-PHE-PRO-ARG-CHLOROMETHYL KETONE | | Authors: | Zogg, T, Brandstetter, H. | | Deposit date: | 2009-08-06 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
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2WPJ
 | | factor IXa superactive triple mutant, NaCl-soaked | | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | | Authors: | Zogg, T, Brandstetter, H. | | Deposit date: | 2009-08-06 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
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2Y6I
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2Y3U
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2Y50
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1S0P
 | | Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum. | | Descriptor: | Adenylyl cyclase-associated protein, MAGNESIUM ION | | Authors: | Ksiazek, D, Brandstetter, H, Israel, L, Bourenkov, G.P, Katchalova, G, Janssen, K.P, Bartunik, H.D, Noegel, A.A, Schleicher, M, Holak, T.A. | | Deposit date: | 2004-01-01 | | Release date: | 2004-01-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | STRUCTURE OF THE N-TERMINAL DOMAIN OF THE ADENYLYL
CYCLASE-ASSOCIATED PROTEIN (CAP) FROM DICTYOSTELIUM DISCOIDEUM
Structure, 11, 2003
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4BTZ
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4BK6
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5LPE
 | | Kallikrein-related peptidase 10 complex with Zn2+ | | Descriptor: | Kallikrein-10, SULFATE ION, ZINC ION | | Authors: | Goettig, P, Debela, M, Magdolen, V, Bode, W, Brandstetter, H. | | Deposit date: | 2016-08-12 | | Release date: | 2016-10-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.
Biol.Chem., 397, 2016
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5LPF
 | | Kallikrein-related peptidase 10 | | Descriptor: | Kallikrein-10, SULFATE ION | | Authors: | Goettig, P, Debela, M, Magdolen, V, Bode, W, Brandstetter, H. | | Deposit date: | 2016-08-12 | | Release date: | 2016-10-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.
Biol.Chem., 397, 2016
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1RFN
 | | HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE | | Descriptor: | CALCIUM ION, P-AMINO BENZAMIDINE, PROTEIN (COAGULATION FACTOR IX), ... | | Authors: | Hopfner, K.-P, Lang, A, Karcher, A, Sichler, K, Kopetzki, E, Brandstetter, H, Huber, R, Bode, W, Engh, R.A. | | Deposit date: | 1999-04-19 | | Release date: | 1999-09-01 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.
Structure Fold.Des., 7, 1999
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4B9R
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4BKD
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5MS3
 | | Kallikrein-related peptidase 8 calcium complex | | Descriptor: | CALCIUM ION, Kallikrein-8 | | Authors: | Debela, M, Magdolen, V, Skala, W, Bode, W, Brandstetter, H, Goettig, P. | | Deposit date: | 2016-12-30 | | Release date: | 2018-01-17 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Specificity profiles and antagonistic Ca2+ and Zn2+ regulation of human KLK8/neuropsin activity by modules identified in crystal structures
To Be Published
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