6PQP
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ... | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | 登録日 | 2019-07-09 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6PQQ
| Cryo-EM structure of human TRPA1 C621S mutant in the apo state | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | 登録日 | 2019-07-09 | 公開日 | 2020-01-08 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6PQO
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | 登録日 | 2019-07-09 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6OF2
| Precursor ribosomal RNA processing complex, State 2. | 分子名称: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | 登録日 | 2019-03-28 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6OF3
| Precursor ribosomal RNA processing complex, State 1. | 分子名称: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | 登録日 | 2019-03-28 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6OF4
| Precursor ribosomal RNA processing complex, apo-state. | 分子名称: | CLP1_P domain-containing protein, Ribonuclease | 著者 | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | 登録日 | 2019-03-28 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6MAT
| Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Rix7 mutant, unknown protein | 著者 | Lo, Y.H, Sobhany, M, Hsu, A.L, Ford, B.L, Krahn, J.M, Borgnia, M.J, Stanley, R.E. | 登録日 | 2018-08-28 | 公開日 | 2019-02-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7. Nat Commun, 10, 2019
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6OO4
| Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 3.3 A | 分子名称: | TRPV2, resiniferatoxin | 著者 | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | 登録日 | 2019-04-22 | 公開日 | 2019-05-29 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. Elife, 8, 2019
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6OT2
| Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution | 分子名称: | Transient receptor potential cation channel subfamily V member 3 | 著者 | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | 登録日 | 2019-05-02 | 公開日 | 2019-05-22 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife, 8, 2019
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6UKS
| ATPgammaS bound mBcs1 | 分子名称: | MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | 登録日 | 2019-10-05 | 公開日 | 2020-02-05 | 最終更新日 | 2020-02-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. Nat.Struct.Mol.Biol., 27, 2020
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7TJ2
| SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA | 分子名称: | RNA (31-MER), Uridylate-specific endoribonuclease nsp15 | 著者 | Frazier, M.N, Krahn, J.M, Butay, K.J, Dillard, L.B, Borgnia, M.J, Stanley, R.E. | 登録日 | 2022-01-14 | 公開日 | 2022-03-23 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Res., 50, 2022
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7MK2
| CryoEM Structure of NPR1 | 分子名称: | Regulatory protein NPR1, ZINC ION | 著者 | Kumar, S, Zhou, Y, Dillard, L, Borgnia, M, Bartesaghi, A, Zhou, P. | 登録日 | 2021-04-21 | 公開日 | 2022-03-16 | 最終更新日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of NPR1 in activating plant immunity. Nature, 605, 2022
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7TQV
| SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA | 分子名称: | RNA (33-MER), Uridylate-specific endoribonuclease | 著者 | Frazier, M.N, Krahn, J.M, Butay, K.J, Dillard, L.B, Borgnia, M.J, Stanley, R.E. | 登録日 | 2022-01-27 | 公開日 | 2022-03-23 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Res., 50, 2022
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6NR3
| Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium | 分子名称: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ... | 著者 | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | 登録日 | 2019-01-22 | 公開日 | 2019-02-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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6NN6
| Structure of Dot1L-H2BK120ub nucleosome complex | 分子名称: | DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Anderson, C.J, Baird, M.R, Hsu, A, Barbour, E.H, Koyama, Y, Borgnia, M.J, McGinty, R.K. | 登録日 | 2019-01-14 | 公開日 | 2019-02-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase. Cell Rep, 26, 2019
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8E4P
| Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | 分子名称: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4M
| The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4L
| The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | 分子名称: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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7TPR
| Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants | 分子名称: | Nanobody 7A3, Nanobody 8A2, Spike glycoprotein | 著者 | Butay, K.J, Zhu, J, Dandey, V.P, Hong, J, Kwon, H.J, Chen, C.Z, Duan, Z, Li, D, Ren, H, Liang, T, Martin, N, Esposito, D, Ortega-Rodriguez, U, Xu, M, Xie, H, Ho, M, Cachau, R, Borgnia, M.J. | 登録日 | 2022-01-25 | 公開日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | 主引用文献 | Camel nanobodies broadly neutralize SARS-CoV-2 variants bioRxiv, 2021
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6NR4
| Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium | 分子名称: | Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | 登録日 | 2019-01-22 | 公開日 | 2019-02-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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6NR2
| Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2 | 分子名称: | (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | 登録日 | 2019-01-22 | 公開日 | 2019-02-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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8E4O
| The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4Q
| The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2 | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4N
| The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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6UKP
| Apo mBcs1 | 分子名称: | Mitochondrial chaperone BCS1 | 著者 | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | 登録日 | 2019-10-05 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. Nat.Struct.Mol.Biol., 27, 2020
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