6NN6

Structure of Dot1L-H2BK120ub nucleosome complex

Summary for 6NN6

EMDB information0458 0459 0460
DescriptorHistone H3.2, Histone H4, Histone H2A type 1, ... (8 entities in total)
Functional Keywordschromatin, structural biology, single particle, cryo-em, histone methyltransferase, nucleosome, dot1l, gene regulation
Biological sourceXenopus laevis (African clawed frog)
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Total number of polymer chains12
Total molecular weight254261.76
Authors
Anderson, C.J.,Baird, M.R.,Hsu, A.,Barbour, E.H.,Koyama, Y.,Borgnia, M.J.,McGinty, R.K. (deposition date: 2019-01-14, release date: 2019-02-13, Last modification date: 2019-02-27)
Primary citation
Anderson, C.J.,Baird, M.R.,Hsu, A.,Barbour, E.H.,Koyama, Y.,Borgnia, M.J.,McGinty, R.K.
Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.
Cell Rep, 26:1681-1690.e5, 2019
PubMed: 30759380 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2019.01.058
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliers9 0.2% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6nn6
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Molmil generated image of 6nn6
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Molmil generated image of 6nn6
rotated about y axis by 90°