2GKJ
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![BU of 2gkj by Molmil](/molmil-images/mine/2gkj) | Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor DL-AZIDAP | Descriptor: | (2R,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase | Authors: | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | Deposit date: | 2006-04-02 | Release date: | 2006-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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4M0D
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2GKE
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![BU of 2gke by Molmil](/molmil-images/mine/2gke) | Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP | Descriptor: | (2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase, ... | Authors: | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | Deposit date: | 2006-04-01 | Release date: | 2006-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1KGQ
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![BU of 1kgq by Molmil](/molmil-images/mine/1kgq) | Crystal Structure of Tetrahydrodipicolinate N-Succinyltransferase in Complex with L-2-aminopimelate and Succinamide-CoA | Descriptor: | (2S)-2-aminoheptanedioic acid, 2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE N-SUCCINYLTRANSFERASE, SUCCINAMIDE-COA | Authors: | Beaman, T.W, Vogel, K.W, Drueckhammer, D.G, Blanchard, J.S, Roderick, S.L. | Deposit date: | 2001-11-28 | Release date: | 2002-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase. Protein Sci., 11, 2002
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1KGT
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![BU of 1kgt by Molmil](/molmil-images/mine/1kgt) | Crystal Structure of Tetrahydrodipicolinate N-Succinyltransferase in Complex with Pimelate and Succinyl-CoA | Descriptor: | 2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE N-SUCCINYLTRANSFERASE, PIMELIC ACID, SUCCINYL-COENZYME A | Authors: | Beaman, T.W, Vogel, K.W, Drueckhammer, D.G, Blanchard, J.S, Roderick, S.L. | Deposit date: | 2001-11-28 | Release date: | 2002-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase. Protein Sci., 11, 2002
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1G2O
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![BU of 1g2o by Molmil](/molmil-images/mine/1g2o) | CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, PURINE NUCLEOSIDE PHOSPHORYLASE | Authors: | Shi, W, Basso, L.A, Tyler, P.C, Furneaux, R.H, Blanchard, J.S, Almo, S.C, Schramm, V.L. | Deposit date: | 2000-10-20 | Release date: | 2001-08-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry, 40, 2001
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1TDT
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4JLF
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![BU of 4jlf by Molmil](/molmil-images/mine/4jlf) | Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase | Descriptor: | Beta-lactamase, PHOSPHATE ION | Authors: | Hazra, S, Kurz, S, Blanchard, J, Bonomo, R. | Deposit date: | 2013-03-12 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother., 57, 2013
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2BUE
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![BU of 2bue by Molmil](/molmil-images/mine/2bue) | Structure of AAC(6')-Ib in complex with Ribostamycin and Coenzyme A. | Descriptor: | AAC(6')-IB, CALCIUM ION, COENZYME A, ... | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | Deposit date: | 2008-03-20 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant. Biochemistry, 47, 2008
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2CIG
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![BU of 2cig by Molmil](/molmil-images/mine/2cig) | Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of INH-NADP a derivative of the prodrug isoniazid. | Descriptor: | (4R)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... | Authors: | Argyrou, A, Vetting, M.W, Aladegbami, B, Blanchard, J.S. | Deposit date: | 2006-03-20 | Release date: | 2006-04-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mycobacterium Tuberculosis Dihydrofolate Reductase is a Target for Isoniazid Nat.Struct.Mol.Biol., 13, 2006
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2BM5
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![BU of 2bm5 by Molmil](/molmil-images/mine/2bm5) | The Structure of MfpA (Rv3361c, P21 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN, SULFATE ION | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | Deposit date: | 2005-03-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA Science, 308, 2005
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2BM6
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![BU of 2bm6 by Molmil](/molmil-images/mine/2bm6) | The Structure of MfpA (Rv3361c, C2221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | Descriptor: | CESIUM ION, PENTAPEPTIDE REPEAT FAMILY PROTEIN | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | Deposit date: | 2005-03-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA Science, 308, 2005
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1Q5N
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2BM4
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![BU of 2bm4 by Molmil](/molmil-images/mine/2bm4) | The Structure of MfpA (Rv3361c, C2 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | Deposit date: | 2005-03-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA Science, 308, 2005
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2BM7
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![BU of 2bm7 by Molmil](/molmil-images/mine/2bm7) | The Structure of MfpA (Rv3361c, P3221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | Deposit date: | 2005-03-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA Science, 308, 2005
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3NDE
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![BU of 3nde by Molmil](/molmil-images/mine/3nde) | |
3NCK
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![BU of 3nck by Molmil](/molmil-images/mine/3nck) | |
3NDG
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3NBL
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![BU of 3nbl by Molmil](/molmil-images/mine/3nbl) | Crystal Structure of BlaC-E166A covalently bound with Cefuroxime | Descriptor: | (2R)-5-[(carbamoyloxy)methyl]-2-[(1R)-1-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase | Authors: | Tremblay, L.W, Blanchard, J.S. | Deposit date: | 2010-06-03 | Release date: | 2011-12-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | BlaC-E166A covalently bound with cephalosporins and penicillins To be Published
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3N8S
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![BU of 3n8s by Molmil](/molmil-images/mine/3n8s) | Crystal Structure of BlaC-E166A covalently bound with Cefamandole | Descriptor: | (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Tremblay, L.W, Blanchard, J.S. | Deposit date: | 2010-05-28 | Release date: | 2010-11-24 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants. Biochemistry, 49, 2010
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3N6I
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2AMA
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![BU of 2ama by Molmil](/molmil-images/mine/2ama) | Crystal structure of human androgen receptor ligand binding domain in complex with dihydrotestosterone | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION | Authors: | Pereira de Jesus-Tran, K, Cote, P.-L, Cantin, L, Blanchet, J, Labrie, F, Breton, R. | Deposit date: | 2005-08-09 | Release date: | 2006-05-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Sci., 15, 2006
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2AM9
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![BU of 2am9 by Molmil](/molmil-images/mine/2am9) | Crystal structure of human androgen receptor ligand binding domain in complex with testosterone | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Androgen receptor, GLYCEROL, ... | Authors: | Pereira de Jesus-Tran, K, Cote, P.-L, Cantin, L, Blanchet, J, Labrie, F, Breton, R. | Deposit date: | 2005-08-09 | Release date: | 2006-05-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Sci., 15, 2006
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3M6B
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![BU of 3m6b by Molmil](/molmil-images/mine/3m6b) | Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase | Descriptor: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Tremblay, L.W, Fan, F, Blanchard, J.S. | Deposit date: | 2010-03-15 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49, 2010
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3N8R
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![BU of 3n8r by Molmil](/molmil-images/mine/3n8r) | |