2CIG
Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of INH-NADP a derivative of the prodrug isoniazid.
Summary for 2CIG
| Entry DOI | 10.2210/pdb2cig/pdb |
| Related | 1DF7 1DG5 1DG7 1DG8 |
| Descriptor | DIHYDROFOLATE REDUCTASE, (4R)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | nadp, isoniazid, reductase, inhibitor, bisubstrate, tuberculosis, oxidoreductase, one-carbon metabolism |
| Biological source | MYCOBACTERIUM TUBERCULOSIS |
| Total number of polymer chains | 1 |
| Total formula weight | 19070.03 |
| Authors | Argyrou, A.,Vetting, M.W.,Aladegbami, B.,Blanchard, J.S. (deposition date: 2006-03-20, release date: 2006-04-25, Last modification date: 2023-12-13) |
| Primary citation | Argyrou, A.,Vetting, M.W.,Aladegbami, B.,Blanchard, J.S. Mycobacterium Tuberculosis Dihydrofolate Reductase is a Target for Isoniazid Nat.Struct.Mol.Biol., 13:408-413, 2006 Cited by PubMed: 16648861DOI: 10.1038/NSMB1089 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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