2CIG
Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of INH-NADP a derivative of the prodrug isoniazid.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DIHYDROFOLATE REDUCTASE | polymer | 159 | 17659.0 | 1 | UniProt (P0A546) Pfam (PF00186) UniProt (by SIFTS) (P9WNX1) | MYCOBACTERIUM TUBERCULOSIS | |
| 2 | B (A) | (4R)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE | non-polymer | 850.5 | 1 | Chemie (1DG) | |||
| 3 | C, D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I (A) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0A546)
| PDB | External Database | Details |
|---|---|---|
| Val 46 | Thr 46 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17659.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1411.0 | |
| All* | Total formula weight | 19070.0 |
