5IBS
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![BU of 5ibs by Molmil](/molmil-images/mine/5ibs) | Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | Deposit date: | 2016-02-22 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
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5IBM
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![BU of 5ibm by Molmil](/molmil-images/mine/5ibm) | Structure of S502P, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | Deposit date: | 2016-02-22 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
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6BN5
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![BU of 6bn5 by Molmil](/molmil-images/mine/6bn5) | Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2 | Descriptor: | 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | Deposit date: | 2017-11-16 | Release date: | 2017-12-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorg. Med. Chem., 25, 2017
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8ESV
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![BU of 8esv by Molmil](/molmil-images/mine/8esv) | |
5VO5
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![BU of 5vo5 by Molmil](/molmil-images/mine/5vo5) | |
5W55
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![BU of 5w55 by Molmil](/molmil-images/mine/5w55) | |
7JIC
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![BU of 7jic by Molmil](/molmil-images/mine/7jic) | Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment | Descriptor: | B-lymphocyte antigen CD19, CD81 antigen, Coltuximab Heavy Chain, ... | Authors: | Susa, K.J, Rawson, S, Kruse, A.C, Blacklow, S.C. | Deposit date: | 2020-07-23 | Release date: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81 Science, 371, 2021
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6PY8
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![BU of 6py8 by Molmil](/molmil-images/mine/6py8) | Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA | Descriptor: | DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... | Authors: | Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. | Deposit date: | 2019-07-29 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
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3NBN
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3I08
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![BU of 3i08 by Molmil](/molmil-images/mine/3i08) | |
5HQG
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![BU of 5hqg by Molmil](/molmil-images/mine/5hqg) | |
5IGO
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![BU of 5igo by Molmil](/molmil-images/mine/5igo) | |
7RDB
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![BU of 7rdb by Molmil](/molmil-images/mine/7rdb) | Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) | Descriptor: | Tetraspanin-15 | Authors: | Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C. | Deposit date: | 2021-07-09 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure, 30, 2022
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7RD5
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![BU of 7rd5 by Molmil](/molmil-images/mine/7rd5) | Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab | Descriptor: | 1C12 Fab Heavy Chain, 1C12 Fab Light Chain, Tetraspanin-15 | Authors: | Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C. | Deposit date: | 2021-07-09 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure, 30, 2022
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6NCE
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![BU of 6nce by Molmil](/molmil-images/mine/6nce) | Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead DNA sequence | Descriptor: | DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), Forkhead box protein N3, ... | Authors: | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | Deposit date: | 2018-12-11 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.598 Å) | Cite: | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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6NCM
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![BU of 6ncm by Molmil](/molmil-images/mine/6ncm) | Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence | Descriptor: | DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), Forkhead box protein N3, ... | Authors: | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | Deposit date: | 2018-12-11 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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4ZLP
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![BU of 4zlp by Molmil](/molmil-images/mine/4zlp) | Crystal Structure of Notch3 Negative Regulatory Region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2015-05-01 | Release date: | 2015-08-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.479 Å) | Cite: | Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
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5IGQ
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![BU of 5igq by Molmil](/molmil-images/mine/5igq) | |
5I6V
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![BU of 5i6v by Molmil](/molmil-images/mine/5i6v) | |
5J45
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![BU of 5j45 by Molmil](/molmil-images/mine/5j45) | |
5L2Q
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![BU of 5l2q by Molmil](/molmil-images/mine/5l2q) | |
4XI7
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![BU of 4xi7 by Molmil](/molmil-images/mine/4xi7) | |
4XIB
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![BU of 4xib by Molmil](/molmil-images/mine/4xib) | |
4XI6
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![BU of 4xi6 by Molmil](/molmil-images/mine/4xi6) | |
5WA5
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![BU of 5wa5 by Molmil](/molmil-images/mine/5wa5) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor XMD11-50 | Descriptor: | 1,2-ETHANEDIOL, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4 | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2017-06-24 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.172 Å) | Cite: | Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
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