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PDB: 150 件
1BZC
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BU of 1bzc by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
分子名称: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
著者Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
登録日1998-10-27
公開日1999-02-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
6Q6H
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BU of 6q6h by Molmil
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
分子名称: Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 13, ...
著者Zhang, S, Barford, D.
登録日2018-12-11
公開日2019-09-11
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Nat Commun, 10, 2019
8Q85
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BU of 8q85 by Molmil
Outer kinetochore Dam1 protomer monomer Ndc80-Nuf2 coiled-coil complex
分子名称: DASH complex subunit ASK1, DASH complex subunit DAD1, DASH complex subunit DAD2, ...
著者Muir, K.W, Barford, D.
登録日2023-08-17
公開日2023-12-06
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules.
Science, 382, 2023
8Q84
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Outer kinetochore Dam1 protomer dimer Ndc80-Nuf2 coiled-coil complex
分子名称: DASH complex subunit ASK1, DASH complex subunit DAD1, DASH complex subunit DAD2, ...
著者Muir, K.W, Barford, D.
登録日2023-08-17
公開日2023-12-06
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules.
Science, 382, 2023
2B4S
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BU of 2b4s by Molmil
Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase
分子名称: Insulin receptor, SULFATE ION, Tyrosine-protein phosphatase, ...
著者Li, S, Depetris, R.S, Barford, D, Chernoff, J, Hubbard, S.R.
登録日2005-09-26
公開日2005-11-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase.
Structure, 13, 2005
5BPW
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BU of 5bpw by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
分子名称: Anaphase-promoting complex subunit 4
著者Kulkarni, K, Yang, J, Zhang, Z, Barford, D.
登録日2015-05-28
公開日2015-09-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
1A6Q
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BU of 1a6q by Molmil
CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION
分子名称: MANGANESE (II) ION, PHOSPHATASE 2C, PHOSPHATE ION
著者Das, A.K, Helps, N.R, Cohen, P.T.W, Barford, D.
登録日1998-02-27
公開日1998-05-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
EMBO J., 15, 1996
5BPT
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BU of 5bpt by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
分子名称: MGC81278 protein
著者Cronin, N, Yang, J, Zhang, Z, Barford, D.
登録日2015-05-28
公開日2015-09-02
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
1B3U
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BU of 1b3u by Molmil
CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
分子名称: PROTEIN (PROTEIN PHOSPHATASE PP2A)
著者Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D.
登録日1998-12-14
公開日1999-04-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
5A31
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BU of 5a31 by Molmil
Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.
分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ...
著者Chang, L, Zhang, Z, Yang, J, Mclaughlin, S.H, Barford, D.
登録日2015-05-26
公開日2015-11-18
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination.
Nature, 522, 2015
6TGB
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BU of 6tgb by Molmil
CryoEM structure of the binary DOCK2-ELMO1 complex
分子名称: Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1
著者Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D.
登録日2019-11-15
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
1W9H
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BU of 1w9h by Molmil
The Structure of a Piwi protein from Archaeoglobus fulgidus.
分子名称: CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ...
著者Parker, J.S, Roe, S.M, Barford, D.
登録日2004-10-13
公開日2005-01-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
5BPZ
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BU of 5bpz by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
分子名称: 1,2-ETHANEDIOL, Anapc5 protein
著者Cronin, N, Yang, J, Zhang, Z, Barford, D.
登録日2015-05-28
公開日2015-09-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
8PKP
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BU of 8pkp by Molmil
Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D.
登録日2023-06-27
公開日2023-07-19
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1
To Be Published
6TLJ
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BU of 6tlj by Molmil
Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Alfieri, C, Barford, D.
登録日2019-12-02
公開日2020-02-19
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Embo Rep., 21, 2020
2YIN
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BU of 2yin by Molmil
STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.
分子名称: DEDICATOR OF CYTOKINESIS PROTEIN 2, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
著者Kulkarni, K.A, Yang, J, Zhang, Z, Barford, D.
登録日2011-05-16
公開日2011-05-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (Dock) Nucleotide Exchange Factors.
J.Biol.Chem., 286, 2011
2XPI
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BU of 2xpi by Molmil
Crystal structure of APC/C hetero-tetramer Cut9-Hcn1
分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT CUT9, ANAPHASE-PROMOTING COMPLEX SUBUNIT HCN1 HCN1/CDC26,20S CYCLOSOME/APC COMPLEX PROTEIN HCN1, CHAPERONE-LIKE PROTEIN HCN1, ...
著者Zhang, Z, Kulkarni, K.A, Barford, D.
登録日2010-08-26
公開日2011-03-30
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Apc/C Subunit Cdc16/Cut9 is a Contiguous Tetratricopeptide Superhelix with a Homo-Dimer Interface Similar to Cdc27
Embo J., 29, 2010
6TM5
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BU of 6tm5 by Molmil
Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Alfieri, C, Barford, D.
登録日2019-12-03
公開日2020-02-19
最終更新日2020-06-17
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Embo Rep., 21, 2020
2BUG
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BU of 2bug by Molmil
Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide
分子名称: HSP90, SERINE/THREONINE PROTEIN PHOSPHATASE 5
著者Cliff, M.J, Harris, R, Barford, D, Ladbury, J.E, Williams, M.A.
登録日2005-06-13
公開日2006-03-16
最終更新日2020-01-15
実験手法SOLUTION NMR
主引用文献Conformational Diversity in the Tpr Domain-Mediated Interaction of Protein Phosphatase 5 with Hsp90.
Structure, 14, 2006
1A17
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BU of 1a17 by Molmil
TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5
分子名称: SERINE/THREONINE PROTEIN PHOSPHATASE 5, SULFATE ION
著者Das, A.K, Cohen, P.T.W, Barford, D.
登録日1997-12-23
公開日1998-04-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.
EMBO J., 17, 1998
2Y4I
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BU of 2y4i by Molmil
KSR2-MEK1 heterodimer
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ...
著者Brennan, D.F, Barford, D.
登録日2011-01-06
公開日2011-01-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.46 Å)
主引用文献A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek
Nature, 472, 2011
2WMO
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BU of 2wmo by Molmil
Structure of the complex between DOCK9 and Cdc42.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-07-02
公開日2009-09-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009
2WMN
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BU of 2wmn by Molmil
Structure of the complex between DOCK9 and Cdc42-GDP.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-DIPHOSPHATE
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-07-02
公開日2009-09-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.391 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009
2WM9
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BU of 2wm9 by Molmil
Structure of the complex between DOCK9 and Cdc42.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GLYCEROL
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-06-30
公開日2009-09-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009
1OEM
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BU of 1oem by Molmil
PTP1B with the catalytic cysteine oxidized to a sulfenyl-amide bond
分子名称: PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
著者Salmeen, A, Andersen, J.N, Myers, M.P, Meng, T.C, Hinks, J.A, Tonks, N.K, Barford, D.
登録日2003-03-28
公開日2003-06-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Redox Regulation of Protein Tyrosine Phosphatase Involves a Sulfenyl-Amide Intermediate
Nature, 423, 2003

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