1WDA
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![BU of 1wda by Molmil](/molmil-images/mine/1wda) | Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with benzoyl-L-arginine amide | 分子名称: | CALCIUM ION, N-[(E)-2-AMINO-1-(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)-2-HYDROXYVINYL]BENZAMIDE, Protein-arginine deiminase type IV, ... | 著者 | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | 登録日 | 2004-05-12 | 公開日 | 2004-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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1WD9
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![BU of 1wd9 by Molmil](/molmil-images/mine/1wd9) | Calcium bound form of human peptidylarginine deiminase type4 (PAD4) | 分子名称: | CALCIUM ION, Protein-arginine deiminase type IV, SULFATE ION | 著者 | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | 登録日 | 2004-05-12 | 公開日 | 2004-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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1WD8
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![BU of 1wd8 by Molmil](/molmil-images/mine/1wd8) | Calcium free form of human peptidylarginine deiminase type4 (PAD4) | 分子名称: | Protein-arginine deiminase type IV | 著者 | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | 登録日 | 2004-05-12 | 公開日 | 2004-07-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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6IIW
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![BU of 6iiw by Molmil](/molmil-images/mine/6iiw) | |
2E1N
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![BU of 2e1n by Molmil](/molmil-images/mine/2e1n) | |
2DEX
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![BU of 2dex by Molmil](/molmil-images/mine/2dex) | Crystal structure of human peptidylarginine deiminase 4 in complex with histone H3 N-terminal peptide including Arg17 | 分子名称: | 10-mer peptide from histone H3, CALCIUM ION, Protein-arginine deiminase type IV, ... | 著者 | Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M. | 登録日 | 2006-02-18 | 公開日 | 2006-04-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4 Proc.Natl.Acad.Sci.Usa, 103, 2006
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2DEW
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![BU of 2dew by Molmil](/molmil-images/mine/2dew) | Crystal structure of human peptidylarginine deiminase 4 in complex with histone H3 N-terminal tail including Arg8 | 分子名称: | 10-mer peptide from histone H3, CALCIUM ION, Protein-arginine deiminase type IV, ... | 著者 | Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M. | 登録日 | 2006-02-18 | 公開日 | 2006-04-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4 Proc.Natl.Acad.Sci.Usa, 103, 2006
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2DEY
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![BU of 2dey by Molmil](/molmil-images/mine/2dey) | Crystal structure of human peptidylarginine deiminase 4 in complex with histone H4 N-terminal tail including Arg3 | 分子名称: | 10-mer peptide from histone H4, CALCIUM ION, Protein-arginine deiminase type IV, ... | 著者 | Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M. | 登録日 | 2006-02-18 | 公開日 | 2006-04-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4 Proc.Natl.Acad.Sci.Usa, 103, 2006
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3ASK
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![BU of 3ask by Molmil](/molmil-images/mine/3ask) | Structure of UHRF1 in complex with histone tail | 分子名称: | E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ZINC ION | 著者 | Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. | 登録日 | 2010-12-16 | 公開日 | 2012-01-25 | 最終更新日 | 2013-06-05 | 実験手法 | X-RAY DIFFRACTION (2.904 Å) | 主引用文献 | Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Proc.Natl.Acad.Sci.USA, 109, 2012
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3ASL
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![BU of 3asl by Molmil](/molmil-images/mine/3asl) | Structure of UHRF1 in complex with histone tail | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ... | 著者 | Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. | 登録日 | 2010-12-16 | 公開日 | 2012-01-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Proc.Natl.Acad.Sci.USA, 109, 2012
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2ZKD
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![BU of 2zkd by Molmil](/molmil-images/mine/2zkd) | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*DCP*DTP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DGP*DC)-3'), ... | 著者 | Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. | 登録日 | 2008-03-19 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
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2ZKG
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![BU of 2zkg by Molmil](/molmil-images/mine/2zkg) | Crystal structure of unliganded SRA domain of mouse Np95 | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1 | 著者 | Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. | 登録日 | 2008-03-19 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
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2ZKE
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![BU of 2zke by Molmil](/molmil-images/mine/2zke) | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | 分子名称: | DNA (5'-D(*DCP*DTP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DAP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DAP*DG)-3'), E3 ubiquitin-protein ligase UHRF1 | 著者 | Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. | 登録日 | 2008-03-19 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
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2ZKF
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![BU of 2zkf by Molmil](/molmil-images/mine/2zkf) | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | 分子名称: | DNA (5'-D(*DCP*DTP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DGP*DA)-3'), DNA (5'-D(P*DCP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DAP*DGP*DA)-3'), E3 ubiquitin-protein ligase UHRF1 | 著者 | Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. | 登録日 | 2008-03-19 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
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2CVD
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![BU of 2cvd by Molmil](/molmil-images/mine/2cvd) | Crystal structure analysis of human hematopoietic prostaglandin D synthase complexed with HQL-79 | 分子名称: | 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE, GLUTATHIONE, GLYCEROL, ... | 著者 | Aritake, K, Kado, Y, Inoue, T, Miyano, M, Urade, Y. | 登録日 | 2005-06-02 | 公開日 | 2006-04-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural and Functional Characterization of HQL-79, an Orally Selective Inhibitor of Human Hematopoietic Prostaglandin D Synthase. J.Biol.Chem., 281, 2006
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3VXV
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![BU of 3vxv by Molmil](/molmil-images/mine/3vxv) | Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*CP*(5CM)P*GP*GP*AP*CP*A)-3'), ... | 著者 | Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M. | 登録日 | 2012-09-21 | 公開日 | 2013-01-16 | 最終更新日 | 2013-08-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4 J.Biol.Chem., 288, 2013
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7FB7
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![BU of 7fb7 by Molmil](/molmil-images/mine/7fb7) | Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, DIMETHYL SULFOXIDE, ... | 著者 | Kori, S, Arita, K, Yoshimi, S. | 登録日 | 2021-07-08 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorg.Med.Chem., 52, 2021
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2RRU
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![BU of 2rru by Molmil](/molmil-images/mine/2rru) | Solution structure of the UBA omain of p62 and its interaction with ubiquitin | 分子名称: | Sequestosome-1 | 著者 | Isogai, S, Morimoto, D, Arita, K, Unzai, S, Tenno, T, Hasegawa, J, Sou, Y, Komatsu, M, Tanaka, K, Shirakawa, M, Tochio, H. | 登録日 | 2011-06-09 | 公開日 | 2011-06-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Crystal structure of the UBA omain of p62 and its interaction with ubiquitin To be Published
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5WVO
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![BU of 5wvo by Molmil](/molmil-images/mine/5wvo) | Crystal structure of DNMT1 RFTS domain in complex with K18/K23 mono-ubiquitylated histone H3 | 分子名称: | DNA (cytosine-5)-methyltransferase 1, Histone H3.1, Ubiquitin, ... | 著者 | Ishiyama, S, Nishiyama, A, Nakanishi, M, Arita, K. | 登録日 | 2016-12-28 | 公開日 | 2017-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance Mol. Cell, 68, 2017
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7XGA
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7XI9
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![BU of 7xi9 by Molmil](/molmil-images/mine/7xi9) | Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form) | 分子名称: | DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... | 著者 | Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Structural basis for activation of DNMT1. Nat Commun, 13, 2022
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6K3A
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![BU of 6k3a by Molmil](/molmil-images/mine/6k3a) | |
7XIB
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![BU of 7xib by Molmil](/molmil-images/mine/7xib) | Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form) | 分子名称: | DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... | 著者 | Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.23 Å) | 主引用文献 | Structural basis for activation of DNMT1. Nat Commun, 13, 2022
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5YY9
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![BU of 5yy9 by Molmil](/molmil-images/mine/5yy9) | Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 | 分子名称: | E3 ubiquitin-protein ligase UHRF1, Ligase 1 | 著者 | Kori, S, Defossez, P.A, Arita, K. | 登録日 | 2017-12-08 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.653 Å) | 主引用文献 | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
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5YYA
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![BU of 5yya by Molmil](/molmil-images/mine/5yya) | Crystal structure of Tandem Tudor Domain of human UHRF1 | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION | 著者 | Kori, S, Defossez, P.A, Arita, K. | 登録日 | 2017-12-08 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
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