7FB7

Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine

Summary for 7FB7

• Entry DOI: 10.2210/pdb7fb7/pdb
• Descriptor: E3 ubiquitin-protein ligase UHRF1, (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, ... (6 entities in total)
• Functional Keywords: dna methylation, histone modification, inhibitor, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 37546.07

Authors

Kori, S.,Arita, K.,Yoshimi, S. (deposition date: 2021-07-08, release date: 2022-01-05, Last modification date: 2023-11-29)

• Primary citation: Kori, S.,Shibahashi, Y.,Ekimoto, T.,Nishiyama, A.,Yoshimi, S.,Yamaguchi, K.,Nagatoishi, S.,Ohta, M.,Tsumoto, K.,Nakanishi, M.,Defossez, P.A.,Ikeguchi, M.,Arita, K.; Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.; Bioorg.Med.Chem., 52:116500-116500, 2021; PubMed: 34801826; DOI: 10.1016/j.bmc.2021.116500

Experimental method

X-RAY DIFFRACTION (1.45 Å)