7FB7
Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase UHRF1 | polymer | 155 | 18249.3 | 2 | UniProt (Q96T88) Pfam (PF12148) In PDB | Homo sapiens (human) | Inverted CCAAT box-binding protein of 90 kDa,Nuclear protein 95,Nuclear zinc finger protein Np95,HuNp95,hNp95,RING finger protein 106,RING-type E3 ubiquitin transferase UHRF1,Transcription factor ICBP90,Ubiquitin-like PHD and RING finger domain-containing protein 1,hUHRF1,Ubiquitin-like-containing PHD and RING finger domains protein 1 |
| 2 | A, B | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 4 | Chemie (MPD) | |||
| 3 | A, B | 5-amino-2,4-dimethylpyridine | non-polymer | 122.2 | 2 | Chemie (8NF) | |||
| 4 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | water | water | 18.0 | 554 | Chemie (HOH) |
Sequence modifications
A, B: 123 - 285 (UniProt: Q96T88)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | - | expression tag |
| - | Ser 165 | deletion |
| - | Arg 166 | deletion |
| - | Asp 167 | deletion |
| - | Glu 168 | deletion |
| - | Pro 169 | deletion |
| - | Cys 170 | deletion |
| - | Ser 171 | deletion |
| - | Ser 172 | deletion |
| - | Thr 173 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36498.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1047.5 | |
| All* | Total formula weight | 37546.1 |
