7XI9

Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form)

This is a non-PDB format compatible entry.

Summary for 7XI9

• Entry DOI: 10.2210/pdb7xi9/pdb
• EMDB information: 33200
• Descriptor: DNA (cytosine-5)-methyltransferase 1, DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), ... (6 entities in total)
• Functional Keywords: dna methyltransferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 151156.98

Authors

Onoda, H.,Kikuchi, A.,Kori, S.,Yoshimi, S.,Yamagata, A.,Arita, K. (deposition date: 2022-04-12, release date: 2022-11-30, Last modification date: 2022-12-07)

• Primary citation: Kikuchi, A.,Onoda, H.,Yamaguchi, K.,Kori, S.,Matsuzawa, S.,Chiba, Y.,Tanimoto, S.,Yoshimi, S.,Sato, H.,Yamagata, A.,Shirouzu, M.,Adachi, N.,Sharif, J.,Koseki, H.,Nishiyama, A.,Nakanishi, M.,Defossez, P.A.,Arita, K.; Structural basis for activation of DNMT1.; Nat Commun, 13:7130-7130, 2022; PubMed: 36414620; DOI: 10.1038/s41467-022-34779-4

Experimental method

ELECTRON MICROSCOPY (2.52 Å)