3TIC
| Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. | 登録日 | 2011-08-20 | 公開日 | 2011-11-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
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3TIA
| Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... | 著者 | Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. | 登録日 | 2011-08-20 | 公開日 | 2011-11-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
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4EMP
| Crystal structure of the mutant of ClpP E137A from Staphylococcus aureus | 分子名称: | ATP-dependent Clp protease proteolytic subunit | 著者 | Ye, F, Zhang, J, Liu, H, Luo, C, Yang, C.-G. | 登録日 | 2012-04-12 | 公開日 | 2013-04-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease J.Biol.Chem., 288, 2013
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7AAB
| Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47 | 分子名称: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | 著者 | Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. | 登録日 | 2020-09-04 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49, 2021
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6JYX
| Structure of CbpJ from Streptococcus Pneumoniae TIGR4 | 分子名称: | CHOLINE ION, Choline binding protein J, DI(HYDROXYETHYL)ETHER | 著者 | Xu, Q, Zhang, J.W, Li, Q, Jiang, Y.L. | 登録日 | 2019-04-29 | 公開日 | 2019-06-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the choline-binding protein CbpJ from Streptococcus pneumoniae. Biochem.Biophys.Res.Commun., 514, 2019
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7AAD
| Crystal structure of the catalytic domain of human PARP1 in complex with olaparib | 分子名称: | 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, Poly [ADP-ribose] polymerase 1, SULFATE ION | 著者 | Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. | 登録日 | 2020-09-04 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49, 2021
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7AAC
| Crystal structure of the catalytic domain of human PARP1 in complex with veliparib | 分子名称: | (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, Poly [ADP-ribose] polymerase 1, SULFATE ION | 著者 | Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. | 登録日 | 2020-09-04 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.593 Å) | 主引用文献 | Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49, 2021
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6XA4
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW241 | 分子名称: | 3C-like proteinase, GLYCEROL, inhibitor UAW241 | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-06-03 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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4IKM
| X-ray structure of CARD8 CARD domain | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, Maltose-binding periplasmic protein, ... | 著者 | Jin, T, Huang, M, Smith, P, Jiang, J, Xiao, T. | 登録日 | 2012-12-26 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4606 Å) | 主引用文献 | The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. Acta Crystallogr.,Sect.F, 69, 2013
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5X40
| Structure of a CbiO dimer bound with AMPPCP | 分子名称: | Cobalt ABC transporter ATP-binding protein, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Bao, Z, Qi, X, Wang, J, Zhang, P. | 登録日 | 2017-02-09 | 公開日 | 2017-04-05 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure and mechanism of a group-I cobalt energy coupling factor transporter Cell Res., 27, 2017
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8UEJ
| ssRNA phage PhiCb5 virion | 分子名称: | CALCIUM ION, Coat protein, Maturation protein | 著者 | Wang, Y, Zhang, J. | 登録日 | 2023-10-01 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanisms of Tad pilus assembly and its interaction with an RNA virus. Sci Adv, 10, 2024
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8UCR
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4RAG
| CRYSTAL STRUCTURE of PPC2A-D38K | 分子名称: | MANGANESE (II) ION, Protein phosphatase 1A | 著者 | Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P. | 登録日 | 2014-09-10 | 公開日 | 2015-08-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The catalytic role of the M2 metal ion in PP2C alpha Sci Rep, 5, 2015
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5XI7
| Crystal structure of T2R-TTL bound with PO-7 | 分子名称: | (6Z)-3-[[2,5-bis(fluoranyl)phenyl]methylidene]-6-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Chu, Y, Wang, Y, Yang, J, Li, W. | 登録日 | 2017-04-26 | 公開日 | 2017-10-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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5XKF
| Crystal structure of T2R-TTL-MPC6827 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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3HI5
| Crystal structure of Fab fragment of AL-57 | 分子名称: | Heavy chain of Fab fragment of AL-57 against alpha L I domain, light chain of Fab fragment of AL-57 against alpha L I domain | 著者 | Zhang, H, Wang, J. | 登録日 | 2009-05-18 | 公開日 | 2009-09-22 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proc.Natl.Acad.Sci.USA, 106, 2009
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6ULW
| Adenylation, ketoreductase, and pseudo Asub multidomain structure of a keto acid-selecting NRPS module | 分子名称: | Amino acid adenylation domain-containing protein, CALCIUM ION, MAGNESIUM ION | 著者 | Alonzo, D.A, Wang, J, Chiche-Lapierre, C, Schmeing, T.M. | 登録日 | 2019-10-08 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nat.Chem.Biol., 16, 2020
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7MRL
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4WF1
| Crystal structure of the E. coli ribosome bound to negamycin. | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Olivier, N.B, Altman, R.B, Noeske, J, Basarab, G.S, Code, E, Ferguson, A.D, Gao, N, Huang, J, Juette, M.F, Livchak, S, Miller, M.D, Prince, D.B, Cate, J.H.D, Buurman, E.T, Blanchard, S.C. | 登録日 | 2014-09-11 | 公開日 | 2014-11-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome. Proc.Natl.Acad.Sci.USA, 111, 2014
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4R7L
| Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 | 分子名称: | ACETATE ION, GLYCEROL, IMIDAZOLE, ... | 著者 | Ouyang, P, Cui, K, Lu, W, Huang, J. | 登録日 | 2014-08-27 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Human Leukotriene A4 Hydrolase in complex with SAHA To be Published
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5XKE
| Crystal structure of T2R-TTL-Demecolcine complex | 分子名称: | (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-07 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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4RAF
| Crystal structure of PP2Ca-D38A | 分子名称: | MANGANESE (II) ION, Protein phosphatase 1A | 著者 | Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P. | 登録日 | 2014-09-10 | 公開日 | 2015-08-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | The catalytic role of the M2 metal ion in PP2C alpha Sci Rep, 5, 2015
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5C8Y
| Crystal structure of T2R-TTL-Plinabulin complex | 分子名称: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | 登録日 | 2015-06-26 | 公開日 | 2015-11-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | 主引用文献 | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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5CA1
| Crystal structure of T2R-TTL-Nocodazole complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yu, Y, Chen, Q, Yang, J. | 登録日 | 2015-06-29 | 公開日 | 2015-11-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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5H3O
| Structure of a eukaryotic cyclic nucleotide-gated channel | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION | 著者 | Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. | 登録日 | 2016-10-26 | 公開日 | 2017-01-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature, 542, 2017
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