6ULW

Adenylation, ketoreductase, and pseudo Asub multidomain structure of a keto acid-selecting NRPS module

Summary for 6ULW

Entry DOI	10.2210/pdb6ulw/pdb
Descriptor	Amino acid adenylation domain-containing protein, CALCIUM ION, MAGNESIUM ION (3 entities in total)
Functional Keywords	nrps, nonribosomal peptide synthetase, non-ribosomal peptide synthetase, adenylation, adenylation domain, depsipeptide, cereulide, valinomycin, natural product, adenylate, keto acid, ketoacid, ketoreductase, short chain dehydrogenase, biosynthetic protein
Biological source	Bacillus stratosphericus LAMA 585
Total number of polymer chains	4
Total formula weight	596067.12
Authors	Alonzo, D.A.,Wang, J.,Chiche-Lapierre, C.,Schmeing, T.M. (deposition date: 2019-10-08, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Alonzo, D.A.,Chiche-Lapierre, C.,Tarry, M.J.,Wang, J.,Schmeing, T.M. Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nat.Chem.Biol., 16:493-496, 2020 Cited by PubMed: 32066969 DOI: 10.1038/s41589-020-0481-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation