7AAC
Crystal structure of the catalytic domain of human PARP1 in complex with veliparib
Summary for 7AAC
Entry DOI | 10.2210/pdb7aac/pdb |
Related | 7AAA 7AAB 7AAD |
Descriptor | Poly [ADP-ribose] polymerase 1, (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, SULFATE ION, ... (4 entities in total) |
Functional Keywords | parp inhibitor, parylation, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 79306.58 |
Authors | Schimpl, M.,Ogden, T.E.H.,Yang, J.-C.,Easton, L.E.,Underwood, E.,Rawlins, P.B.,Johannes, J.W.,Embrey, K.J.,Neuhaus, D. (deposition date: 2020-09-04, release date: 2021-01-13, Last modification date: 2024-05-01) |
Primary citation | Ogden, T.E.H.,Yang, J.C.,Schimpl, M.,Easton, L.E.,Underwood, E.,Rawlins, P.B.,McCauley, M.M.,Langelier, M.F.,Pascal, J.M.,Embrey, K.J.,Neuhaus, D. Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49:2266-2288, 2021 Cited by PubMed: 33511412DOI: 10.1093/nar/gkab020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.593 Å) |
Structure validation
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