7AAA

Crystal structure of the catalytic domain of human PARP1 (apo)

Summary for 7AAA

• Entry DOI: 10.2210/pdb7aaa/pdb
• Descriptor: Poly [ADP-ribose] polymerase 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: parp, parylation, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 79132.39

Authors

Schimpl, M.,Ogden, T.E.H.,Yang, J.-C.,Underwood, E.,Rawlins, P.B.,Johannes, J.W.,Easton, L.E.,Embrey, K.J.,Neuhaus, D. (deposition date: 2020-09-04, release date: 2021-01-13, Last modification date: 2021-03-10)

• Primary citation: Ogden, T.E.H.,Yang, J.C.,Schimpl, M.,Easton, L.E.,Underwood, E.,Rawlins, P.B.,McCauley, M.M.,Langelier, M.F.,Pascal, J.M.,Embrey, K.J.,Neuhaus, D.; Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.; Nucleic Acids Res., 49:2266-2288, 2021; PubMed: 33511412; DOI: 10.1093/nar/gkab020

Experimental method

X-RAY DIFFRACTION (1.74 Å)