7AAA
Crystal structure of the catalytic domain of human PARP1 (apo)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1101 |
| Chain | Residue |
| A | LYS903 |
| A | LEU984 |
| A | LEU985 |
| A | TYR986 |
| A | HOH1217 |
| A | HOH1228 |
| A | HOH1380 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 1102 |
| Chain | Residue |
| A | LYS953 |
| A | HOH1237 |
| A | HOH1249 |
| A | HOH1256 |
| A | HOH1259 |
| A | HOH1361 |
| B | GLN718 |
| B | GLN722 |
| A | LYS703 |
| A | ARG704 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 1103 |
| Chain | Residue |
| A | HIS862 |
| A | GLY863 |
| A | SER904 |
| A | TYR907 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 1101 |
| Chain | Residue |
| A | GLN722 |
| B | LYS903 |
| B | LEU984 |
| B | LEU985 |
| B | TYR986 |
| B | HOH1201 |
| B | HOH1264 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1102 |
| Chain | Residue |
| B | ASP766 |
| B | ILE879 |
| B | ALA880 |
| B | TYR889 |
| B | LYS893 |
| B | GLY894 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue DMS B 1103 |
| Chain | Residue |
| B | TRP861 |
| B | HIS862 |
| B | GLY863 |
| B | TYR896 |
| B | PHE897 |
| B | SER904 |
| B | TYR907 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Domain: {"description":"PARP alpha-helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00398","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7852410","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9315851","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UGN5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
