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PDB: 24 件
5LHS
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BU of 5lhs by Molmil
The ligand free catalytic domain of murine urokinase-type plasminogen activator
分子名称: NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.047 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
3M61
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BU of 3m61 by Molmil
Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition
分子名称: Urokinase-type plasminogen activator, upain-1 W3A
著者Jiang, L, Yuan, C, Wind, T, Andreasen, P.A, Chen, L, Meehan, E.J, Huang, M.
登録日2010-03-15
公開日2010-04-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition
TO BE PUBLISHED
3UT3
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A novel PAI-I inhibitor and its structural mechanism
分子名称: 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione, Plasminogen activator inhibitor 1
著者Lin, Z.H, Hong, Z.B, Shi, X.L, Hu, L.H, Andreasen, P.A, Huang, M.D.
登録日2011-11-25
公開日2013-02-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献A novel PAI-I inhibitor and its structural mechanism
To be Published
5EZD
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BU of 5ezd by Molmil
Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1
分子名称: ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION
著者Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K.
登録日2015-11-26
公開日2016-05-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
6A8N
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BU of 6a8n by Molmil
The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5
分子名称: CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS, Urokinase-type plasminogen activator B
著者Wang, D, Yang, Y.S, Jiang, L.G, Huang, M.D, Li, J.Y, Andreasen, P.A, Xu, P, Chen, Z.
登録日2018-07-09
公開日2019-02-20
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.489 Å)
主引用文献Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
6A8G
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BU of 6a8g by Molmil
The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5
分子名称: PHOSPHATE ION, Urokinase-type plasminogen activator chain B, muPAin-1-IG
著者Wang, D, Yang, Y.S, Jiang, L.G, Huang, M.D, Li, J.Y, Andreasen, P.A, Xu, P, Chen, Z.
登録日2018-07-08
公開日2019-02-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
2NWN
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BU of 2nwn by Molmil
New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1
分子名称: Plasminogen activator, urokinase, upain-1
著者Zhao, G, Yuan, C, Wind, T, Andreasen, P.A, Huang, Z, Huang, M, Structural Genomics Consortium (SGC)
登録日2006-11-16
公開日2007-10-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
5LHR
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BU of 5lhr by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22
分子名称: Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
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BU of 5lhp by Molmil
The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
分子名称: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ...
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHN
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BU of 5lhn by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
分子名称: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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BU of 5lhq by Molmil
The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
分子名称: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
著者Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
登録日2016-07-12
公開日2017-06-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
4DW2
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BU of 4dw2 by Molmil
The crystal structure of uPA in complex with the Fab fragment of mAb-112
分子名称: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-24
公開日2013-01-16
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
5HGG
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BU of 5hgg by Molmil
Crystal structure of uPA in complex with a camelid-derived antibody fragment
分子名称: (3S)-3-[(2S,3S,4R)-3,4-DIMETHYLTETRAHYDROFURAN-2-YL]BUTYL LAURATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Camelid Derived Antibody Fragment, ...
著者Yung, K.W.Y, Kromann-Hansen, T, Andreasen, P.A, Ngo, J.C.K.
登録日2016-01-08
公開日2016-06-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior
J.Biol.Chem., 291, 2016
4ZKO
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BU of 4zko by Molmil
The crystal structure of upain-1-W3A in complex with uPA at pH7.4
分子名称: C-terminal fragment of upain-1-W3A, HEXAETHYLENE GLYCOL, N-terminal fragment of upain-1-W3A, ...
著者Jiang, L, Andreasen, P.A, Huang, M.
登録日2015-04-30
公開日2016-05-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKR
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BU of 4zkr by Molmil
The crystal structure of upain-1-W3A in complex with uPA at pH9.0
分子名称: HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator, ...
著者Jiang, L, Andreasen, P.A, Huang, M.
登録日2015-04-30
公開日2016-05-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKS
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BU of 4zks by Molmil
The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4
分子名称: Urokinase-type plasminogen activator, upain-1-W3A
著者Jiang, L, Andreasen, P.A, Huang, M.
登録日2015-04-30
公開日2016-05-18
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKN
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BU of 4zkn by Molmil
The crystal structure of upain-1-W3A in complex with uPA at pH5.5
分子名称: SULFATE ION, TETRAETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
著者Jiang, L, Andreasen, P.A, Huang, M.
登録日2015-04-30
公開日2016-05-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZHL
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BU of 4zhl by Molmil
The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
分子名称: Urokinase-type plasminogen activator, mupain-1-IG
著者Jiang, L, Andreasen, P.A, Huang, M.
登録日2015-04-25
公開日2015-09-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427, 2015
4ZHM
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BU of 4zhm by Molmil
The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4
分子名称: Urokinase-type plasminogen activator, mupain-1-16-IG, piperidine-1-carboximidamide
著者Jiang, L, Andreasen, P.A, Huang, M.
登録日2015-04-25
公開日2015-09-16
最終更新日2015-10-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427, 2015
4DVB
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BU of 4dvb by Molmil
The crystal structure of the Fab fragment of pro-uPA antibody mAb-112
分子名称: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, TETRAETHYLENE GLYCOL
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-23
公開日2013-01-16
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
4DVA
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BU of 4dva by Molmil
The crystal structure of human urokinase-type plasminogen activator catalytic domain
分子名称: HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-23
公開日2013-01-16
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody
Biochem.J., 449, 2013
3OX7
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BU of 3ox7 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH4.6
分子名称: MH027, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-21
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY6
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BU of 3oy6 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6
分子名称: MH036, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
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BU of 3oy5 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4
分子名称: MH027, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011

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