5EZD

Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1

Summary for 5EZD

Entry DOI	10.2210/pdb5ezd/pdb
Descriptor	Kunitz-type protease inhibitor 1, POTASSIUM ION, ACETATE ION, ... (4 entities in total)
Functional Keywords	transmembrane, multidomain, serine protease inhibitor, tertiary structure, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Secreted: O43278
Total number of polymer chains	2
Total formula weight	33765.88
Authors	Hong, Z.,Andreasen, P.A.,Morth, J.P.,Jensen, J.K. (deposition date: 2015-11-26, release date: 2016-05-18, Last modification date: 2024-01-10)
Primary citation	Hong, Z.,De Meulemeester, L.,Jacobi, A.,Pedersen, J.S.,Morth, J.P.,Andreasen, P.A.,Jensen, J.K. Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J.Biol.Chem., 291:14340-14355, 2016 Cited by PubMed: 27189939 DOI: 10.1074/jbc.M115.707240 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation